摘要
饮食及血清维生素的流行病学研究提示维生素与癌症有关，但也有不同的报道。为此，我们设计了细胞维生素的测定方法，并取２０例胃癌手术标本，分离癌区、癌旁区及正常粘膜区的细胞，测定细胞内维生素Ａ、Ｅ、Ｃ、Ｂ１２、叶酸及β－胡萝卜素的含量，以７例非癌胃为对照。结果表明，胃癌区及癌旁区细胞内维生素Ａ、Ｅ、Ｂ１２及β－胡萝卜素均显著低于非癌胃对应区细胞内含量（Ｐ＜００１），但胃癌区与癌旁区之间无差异。本文初步证实胃癌与维生素的关系，并显示这种关系在癌前阶段细胞内即已发生，因而提示纠正癌前病变细胞内维生素代谢有可能干预胃癌的生成，值得研究。
n order to study further the relationship between gastric cancer
and vitamins,assays forestimation of cellular vitamins were designed,and 27 resected
stomach specimens(20 cancersand 7 non-cancer lesions)were subject to such determination.
The tissues from the cancer orbenign lesions,the para-cancer or para-lesion mucosae and
normal mucosae were taken out,the mucosal cells of the above three parts were isolated,and
the cellular concentration ofvitamin A、E、C、B12,folic acid and β-carotene were determined.
The results showed that thecellular levels of vitamin A、E、B12,and β-carotene in the cancer
and para-cancer mucosaewere significantly lower than those in the corresponding benign
lesion and para-lesionmucosae(P<0.01),but no statistical difference between the cancerous and
the paracancermucosa cells.This paper confirmed an interrelationship existing in between
gastric cancergrowth and vitamins,and that,this kind of correlation might have been present
already inthe precancerous cells. It may be then possible to intervene the process of
gastriccancinogensis by correcting the abnormal vitamin metabolism in the precancerous
stage.
出处
《中华消化杂志》
CAS
CSCD
北大核心
1994年第1期28-30,共3页
Chinese Journal of Digestion
关键词
胃肿瘤
癌前病变
细胞内维生素
Gastric cancer
Precancerous lesions
Intracellular vitamins
β-carotene.
