摘要
目的探讨利用血清游离前列腺特异性抗原(fPSA)和总前列腺特异性抗原(tPSA)的比值(f/tPSA),提高tPSA2.6～4.0ng/ml前列腺癌的诊断率的价值。方法对117例tPSA在2.6～4ng/ml可疑前列腺癌患者行直肠B超引导下前列腺穿刺活检,对患者血清tPSA,fPSA及f/t PSA值及其他临床病理资料进行统计学分析。结果经病理诊断良性前列腺增生(BPH)82例和前列腺癌35例,35例癌中Gleason score≤4分共6例(17%),Gleason score5-7分和8-10分别为22例(63%)和7例(20%)。前列腺癌的f/tPSA明显高于BPH(P＜0.01),以f/tPSA0.22为界值,诊断癌的特异性为83%,敏感性为71%,阳性预测值为68%。结论f/t PSA作为一项辅助检查可提高tPSA 2.6～4.0ng/ml前列腺癌的诊断率。
Objective To examine the usefulness of the percent of free prostate specific antigen （fPSA） to total prostate specific antigen （tPSA） in men with serum tPSA concentration of 2.6 to 4.0 ng/ml. Methods Serum tPSA, fPSA and f/tPSA in 35 cases of prostate cancer and 82 cases of BPH （benign prostatic hyperplasia） were assessed and evaluated when the tPSA level are 2.6-4.0ng/ml. Results f/tPSA was significantly discriminating between benign and malignant diseases （P〈0.01）. The predictive value of f/tPSA of 0.22 was 68% maintaining at least 71% sensitivity and 83% specifity. Conclusion In patients with tPSA values between 2.6-4.0ng/ml the threshold value of f/tPSA of 0.22 can be used to eliminate unnecessary biopsies with minimal loss of cancer patients.
出处
《中国男科学杂志》
CAS
CSCD
2006年第3期43-46,50,共5页
Chinese Journal of Andrology
关键词
前列腺肿瘤
诊断
prostatic neoplasms
diagnosis
