摘要
目的 建立测定罗格列酮缓释片含量的方法。方法 采用高效液相色谱法，以十八烷基硅烷键舍硅胶为固定相，0．05mol／L醋酸钠（用冰醋酸调pH6．0）-甲醇（体积比25：75）为流动相，检测波长247nm，测定盐酸罗格列酮缓释片的含量。结果盐酸罗格列酮在10，15—60．90μg·mL浓度范围内有良好的线性关系（r=0．9998）。回收率为100．3％（RSD=0．65％）。结论 本法测定罗格列酮缓释片的含量，结果准确，可行。
Objective To establish a method for the determination of rosiglitazone in sustained-release tablets. Method HPLC was performed on a C18 column （250 mm × 4.6 mm,5μm） using 0.05 mol/L sodium acetate （pH 6.0）-methanol （25：75） as the mobile phase at a flow rate of 1.0 mL · min^-1 The detection wavelength was at 247 nm. Results The standard curve was linear in the range of 10.15 -60.90μg· mL^-1 with correlation coefficient 0. 9998. The average recovery was 100.3% with RSD 0. 65%. Conclusion The method is convenient, accurate and reliable for the quality control of rosiglitazone sustained-release tablets.
出处
《广东药学院学报》
CAS
2006年第1期41-42,共2页
Academic Journal of Guangdong College of Pharmacy
基金
广州市科技计划项目(2003E2-E4062)
