摘要
目的:通过观察经前平颗粒对中枢神经递质受体亚型的表达,探讨中药治疗情志障碍及经前期综合征(PMS)的微观机制。方法:PMS肝气逆症大鼠模型分别给予不同药物,连续4个月经周期,免疫组化法检测海马5-HT1A受体、5-HT2受体阳性细胞。结果:经前平颗粒能缓解焦虑症状,并使模型大鼠海马5-HT1A受体阳性细胞率明显增多(P<0.05),5-HT2受体阳性细胞率显著减少(P<0.05)。结论:中药经前平颗粒可通过调节中枢5-HT1A和5-HT2受体的表达,治疗与PMS有关的情志障碍。
Objective： To explore the micro-mechanism on feeling obstacle and premenstrual syndrome（PMS） by observing herbal on the expression of the neurotransmiter receptor in neutron. Methods： give PMS model rats with liver-qi invasion different medicine for four menstrual periods,and check the positive cell of 5-HT1A and 5-HT2 receptor in the rat hippocampi by immunohistoehemistry method. Results：Jingqianping granule can relax the anxiety symptom, and significantly increase the positive cell of 5-HTIA, and significantly lower the positive cell expression of 5-HT2 receptor in hippocampi of PMS model rat（P〈 0.05）. Conclusion： Jingqianping granule could treat feeling obstacle related with PMS by controlling the expressin of 5-HT1A and 5-HT2 receptor in central nervous system.
出处
《山东中医药大学学报》
2006年第2期159-161,共3页
Journal of Shandong University of Traditional Chinese Medicine
基金
国家自然科学基金资助项目(编号:30171131)
山东省自然科学基金资助项目(编号:Z2003C01)
