摘要
目的:从调节血清神经递质水平的角度,探讨"经前平颗粒"治疗经前期综合征(PMS)肝气逆证的作用机制。方法:采用随机双盲对照方法,对66例受试者治疗2个月经周期,于治疗前后的卵泡期、黄体期采集血样,以高效液相色谱法检测5-羟色胺(5-HT)、去甲肾上腺素(NE)、肾上腺素(E)的含量。结果:与治疗前相比,经前平组患者,卵泡期和黄体期的5-HT、NE水平明显降低(P<0.01),而安慰剂组患者上述指标无差异;治疗后组间比较,经前平组患者月经同期5-HT、NE水平明显低于安慰剂组(P<0.01)。在以上比较中,E水平均无差异。结论:经前平颗粒可能是通过改善血清神经递质水平,进而调整神经内分泌平衡发挥其治疗作用的。
Objective：From the perspective of the regulation of serum levels of neurotransmitters,it is to approach the medicative mechanism of Jingqianping granule treatment of PMS with liver-qi invasion.Method：66 cases met the liver-qi invasion of PMS inclusion criteria were researched in double blind randomized controlled study for two menstrual cycles.The blood samples of pre-treatment and post treatment were collected.The levels of 5-HT,NE and E were examined.Result：After Jingqianping granule treatment,the levels of 5-HT and NE were decreased markedly（P0.01）in the follicular period and luteal phase.While those biochem indexes were not changed in the placebo group.Conclusion：The medicative mechanism of Jingqianping granule on PMS may be that it can improve the serum levels of neurotransmitters.The PMS patients are cured by establishing the neural-endocrine balance of the internal environment.
出处
《辽宁中医药大学学报》
CAS
2012年第12期45-47,共3页
Journal of Liaoning University of Traditional Chinese Medicine
基金
科技部十五攻关资助课题(2004BA721A04)
关键词
前期综合征
肝气逆证
经前平颗粒
神经递质
premenstrual syndrome
Jingqianping granule
liver-qi invasion
neurotransmitter
