摘要
目的在大鼠动脉钙化模型上观察复方丹参滴丸对钙化血管的作用和钙沉积部位的改变情况。方法28只大鼠随机分为正常对照组、维生素D组和复方丹参组。维生素D组和复方丹参组用维生素D3乳剂灌胃3天,对照组在同等时刻给予等容量对照乳剂灌胃。从实验第4天至第9周结束,复方丹参组每日给予复方丹参滴丸溶于生理盐水中灌胃,另两组分别给予等容量生理盐水灌胃。9周末取胸主动脉做病理切片,并检测血管、骨组织钙和血脂、血钙水平。结果维生素D诱发的血管钙化和骨质疏松模型成功,病理可见明显的钙化结节,且维生素D组与对照组比较血管壁钙含量明显增加,而骨钙则明显减少;复方丹参组与维生素D组和对照组比较差异有显著性。结论复方丹参滴丸可抑制血管钙化,并能将钙转移到骨骼刺激骨形成。
Aim To investigate the role of complex dribbing-pill of danshen pills（DSP） to the calcific vessels and the change of the calcium deposition on the model of vascular calcification in rats. Methods 28 rats were divided into 3 groups rademly： control group（n =9）, VitD group（n= 10）, VitD＋ DSPgroup（n=9）. VitD group and VitD＋ DSP group were given by VitD and rats at control group were given the control medicine at the same volume and time. From the fourth day to the ninth week, theVitD ＋ DSP group was given by 15 pills DSP and to the other groups were given by NaCl. At the end of the ninth week, to analyze the role of DSP to the vascular calcification and the effect of calcium deposition, pathological sections with the rats＇ thoracic aorta were made and calcium in blood, vessels and bones were detected, and so on. Results The model of vascular calcification and osteoporosis with VitD had been succeeded. There were typical calcific nods in vessels. The levels of calcium in vessels in VitD group were obviously higher than those in control group, but the levels of calcium in bones in VitD group were lower than those in control group. DSP can inhibit vascular calcification and transfer the calcium to bones to promote them formation. Significant difference were observed in 3 groups. Conclusion DSP can inhibit vascular calcification availavly and transfer the calcium to bones to promote them formation.
出处
《中国动脉硬化杂志》
CAS
CSCD
2005年第5期571-574,共4页
Chinese Journal of Arteriosclerosis
