摘要
目的:探讨胃肠肿瘤根治手术后无可测量病灶患者血浆TuM2PK变化规律。方法:采用ELISA方法测定37例胃肠肿瘤根治术后无可测量病灶患者血浆TuM2PK的含量并分析。结果:血浆TuM2PK含量分别为:对照组(8.6±3.4)U/ml;术后1个月组(38.5±26.2)U/ml,术后2个月组(22.1±18.2)U/ml;术后3个月以上组(14.6±13.2)U/ml。以≥15U/ml为界,四组阳性检出率分别为0%、78.4%、48.1%、29.7%。对照组与肿瘤各组间含量差异有显著性(P<0.01)。结论:胃肠肿瘤根治手术后无可测量病灶时血浆TuM2PK浓度与手术时间呈负相关。动态检测血浆TuM2PK对于胃肠肿瘤术后的诊断、治疗效果和预后评价具有应用价值,是一个更为理想的、新的、敏感的广谱肿瘤标记物。
Objective To investigate the clinical value of the plasma M2-PK concentration changes changes in post-operative gastrointestinal cancer patients. Method M2-PK levels were determined in EDTA anti-coagulated plasma from 37 post-operative gastrointestinal cancer patients and 32 healthy control individuals by ELISA. Results The tumor M2-PK-concentrations were （8.6±3.4）U/ml, （8.5±26.2）U/ml, （22.1±18.2）U/ml and （14.1±13.2）U/ml for the control group and the post-oporative groups in 1 month, 2 months and beyond 3 months respectively. The cut-off value of 15 U/ml taken, the positive rate of the five groups were 0%, 78.4%, 48.1% and 29.7% respectively. Conclusion Tumor relevant M2-PK concentration has negative correlation with time after gastrointestinal tumor operation. For the post-operative gastrointestinal cancer patientst of follow up the plasma M2-PK concertration has important value in the diagnosis, evaluation of treatment effiency and the prognosis, M2-PK might provide to be an ideal, novel and sensitive tumor marker broady used in the future.
出处
《实用医技杂志》
2006年第3期350-352,共3页
Journal of Practical Medical Techniques
