摘要
目的探讨医院常见病原菌对环丙沙星的耐药性变迁，为临床合理用药提供参考依据。方法用常规鉴定方法分离鉴定病原菌，用K—B法作体外耐药监测。结果从2000-2004年5年临床常见病原菌对环丙沙星耐药率呈上升趋势，总耐药率从2000年的40．8％上升到2004年的51．7％；耐药率居前3位的分别是大肠埃希菌、凝固酶阴性葡萄球菌和金黄色葡萄球菌。结论必须在药敏结果的指导下合理使用以环丙沙星为代表的氟喹诺酮类抗菌药物，控制细菌的耐药性增长。
OBJECTIVE To investigate drug resistance status of common bacteria to ciprofloxacin in hospital for reasonable use of antibiotics. METHODS After genus identification, drug resistance profile was analyzed by K-B method. RESULTS The resistant rate of common bacteria to ciprofloxacin ascended yearly from 40.8% （2000） to 51.7%（2004）, which predominated with Escherichia coli, coagulase negative Staphylococcus and S. aureus, respectively. CONCLUSIONS Rational use of fluoroquinolones should be obey the results of laboratory antibiotics suceptibility test to control the increasing trend of resistance.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2006年第2期216-217,共2页
Chinese Journal of Nosocomiology
关键词
环丙沙星
耐药性
病原菌
Ciprofloxacin
Drug resistance
Bacteria
