摘要
目的探讨医院感染铜绿假单胞菌(PA)的耐药性,为医院感染的监测与控制提供依据。方法采用法国梅里埃生物API鉴定系统进行PA鉴定,并采用K-B纸片扩散法进行体外耐药监测及统计耐药率。结果2年中检出179株PA,其中对耐亚胺培南铜绿假单胞菌(IRPA)占总株数的12.8%;PA分离率最高的病区为重症监护病房(ICU),占35.8%;其次为外三科(16.2%);内一科(15.1%)。PA药物敏感率最高的是多黏菌素E(100%),其次为美罗培南(86.6%)和亚胺培南(82.7%)。耐药率最高的药物是氨苄西林/舒巴坦(95.0%)和复方新诺明(91.6%)。IRPA对15种常规抗菌药物的耐药率明显高于非耐药株,IRPA除对多黏菌素E无耐药外,对其余14种抗菌药物耐药率均大于50%。结论PA的耐药性已十分严重,必须进行严密的监控,预防PA导致的医院感染暴发流行。
Objective To investigate the nosocomial infection and drug resistance of pseudomonas aeruginosa（PA） in our hospital for obtaining the evidence of clinical monitoring and control of nosocomial infection.Methods The microbio1ogical system API was used to identify PA while the drug resistance in vitro was determined by K-B methods.Results Among 179 strains of PA of two years,imipenem resistant P.aeruginosa（IRPA） accounted for 12.8%.The highest isolating rates occurred in the intensive care unit（ICU）,accounted for 35.8%.The following was the Third Department of Surgery,accounted for 16.2%.The First Department of Internal Medicine rated the third,accounted for 15.1%.The highest rate of drug sensitivity of Pseudomonas aeruginosa was polymyxin E（100%）,followed by meropenem（86.6%） and imipenem（82.7%）.The highest rate of drug-resistance was ampicillin / sulbactam（95.0%） and cotrimoxazole（91.6%）.The resistance of imipenem-resistant Pseudomonas aeruginosa（IRPA） to 15 kinds of common antibiotics was significantly higher than that of imipenem-sensitive P.aeruginosa（ISPA）.Except the drug-resistance of IRPA to polymyxin E was of no resistance, the resistance of all other fourteen antibiotics were over 50 %.Conclusion The drug-resistance of PA is very serious in our hosptial.We should perform rigorous monitoring and make a great effort to prevent the outbreak of nosocomial infection with PA.
出处
《检验医学与临床》
CAS
2010年第6期493-495,共3页
Laboratory Medicine and Clinic
关键词
铜绿假单胞菌
医院感染
耐药性
pseudomonas aeruginosa
sosocomial infection
drug-resistance
