摘要
目的:观察葡萄球菌激酶对大鼠颈动脉血栓的溶栓作用和特点。方法:通过电刺激法形成大鼠颈动脉混合性血栓,观察葡萄球菌激酶对血栓的溶解作用,同时测定优球蛋白溶解时间,纤维蛋白原水平,纤维蛋白(原)降解产物值(FDP),D-二聚体(D-D)值。结果:葡萄球菌激酶对大鼠颈动脉血栓具有明显的溶栓作用(46．8％);溶栓过程中优球蛋白溶解时间缩短,纤维蛋白原含量升高(P<0．05或P<0．01),FDP值及D-二聚体值较正常对照组明显升高(P<0．01)。结论:葡萄球菌激酶具有纤维蛋白特异性的溶栓作用。
Objective： To study the thrombolytic effects of staphylokinase in experimental carotid thrombosis model in rats. Methods ： Model of electrically stimulated carotid thrombosis in rat was used to observe the antithrombotic effect of staphylokinase. The euglobulin lytie time （ELT）, level of fibrin degradation production （FDP）, D-Dimmer （D -D） and flbrinogen in blood were assayed after intravenous infusion with staphylokinase and normal saline. Results： Staphylokinase decreased the weight of carotid thrombus of rats obviously （46.8% ） ; lessened ELT and increased the value of Fg （120μg/kg） （P〈0.05-〈0.01） in staphylokinase group compared with normal saline group. The levels of FDP and D,D increased （P〈0. 01） in every carotid thrombosis group compared with normal group. Conclusion： Staphylokinase possesses excellent thrombolytic effects on thrombus.
出处
《心血管康复医学杂志》
CAS
2006年第1期33-35,共3页
Chinese Journal of Cardiovascular Rehabilitation Medicine
