摘要
近年来对溶栓剂的研究取得了很好的成果,主要集中在单链尿激酶型纤溶酶原激活剂(scuPA),组织型纤溶酶原激活剂(tPA),葡萄球菌激酶(SaK)等。葡萄球菌激酶(SaK)是一种激活溶纤维蛋白的制剂,它与纤溶酶原(Plg)形成1∶1的复合体,使后者转变为纤溶酶(Pli)后激活其他分子变为Pli。从葡激酶的溶栓作用机制,包括与纤溶酶(原)等因子的结合作用,葡激酶的高级结构,抗原性等问题以及近年来有关葡激酶作为新一代溶栓的研究进展进行了综述,并指出进一步利用蛋白质工程,对葡激酶进行分子改造的设想。
Recently great progress has been made in thrombolytic study. It mainly focused at singlechained plasminogen （Pig） activator of urokinase type （scu-PA）, plasminogen of tissue type （t-PA）, and staphylokinase （Sak） etc.Staphylokinase is a kind of plasminogen thrombolytic. It combined with Pig to form 1 ： 1 composite. It then made later into Pli and activate the other molecules. Progress in thrombolytic mechanism of staphylokinase, including the link of it with plaminogen and other factor, the high-level structure, antigenicity of staphylokinase and other issues were summarized in this paper. Furthermore, the anticipation of how to make use of protein engineering to improve the staphylokinase at molecular level was also discussed.
出处
《微生物学杂志》
CAS
CSCD
2005年第3期73-76,共4页
Journal of Microbiology
