摘要
目的：探讨小剂量达必佳在体外受将胚胎移植（IVF-ET）卵巢反应欠佳患者中的应用效果。方法：选择接受IVF-ET治疗应用常规长方案促排卵获卵数4-6个，因治疗失败，3月后进行第2次IVF助孕的患者62例，第1个治疗周期每日皮下注射达必佳1支（0.1mg），第2治疗周期达必佳用量为每日1／3支（0．03mg），自身对照比较促性腺激素（Gn）用量、获卵数、受精卵数、冷冻胚胎数。结果：第2周期Gn用量明显少于第1周期（38．46±10．13支vs44、50±13．10支，P〈Q05）；使用Gn前血黄体生成素（LH）水平高于第1周期（2、89±0．41IU／Lvs1．20±0．31IU／L，P〈0．001）；绒毛膜促性腺激素（HCG）注射日血LH、雌二醇（E2）水平高于第1周期（3．39±0．98IU／LVs1．25±Q29IU／L，P〈0．001；6082．11±1011．3pmol／LVS4299．81±1122．40pmol／L，P〈Q05）；获卵数多于第1周期（6、7±0．32个VS5．0±0．68个，P〈0．05）；受精卵数多于第1周期（4．9±0．85个VS3、49±Q35个，P〈0.05）；冷冻胚胎数多于第1周期（2.1±0．42个vs0．97±0．65个，P〈0.05）；而Gn用药时间、降调节后血E2、HCG注射日血孕酮（P）、优质胚胎率等在2个治疗周期问无统计学差异，62例患者第2个IVF周期21例妊娠。结论：对卵巢反应欠佳患者应用1／3剂量达必佳即可达到降调节的效果，且在减少Gn用量的同时，获得满意的妊娠效果。
Objective： To evaluate the effect of one-third dose of GnRHa （ Gonadotrophin releasing hormone agonist） on the poor response patients in IVF-ET. Methods：Sixty- two patients who had got 4-6 oocytes in the first IVF-ET cycle accepted the second IVF-ET cycle with a long suppression protocol. Down-regulation with Decapeptyle injections was started in the midluteal phase at a dose of 0. lmg/d in the first cycle and 0.03mg/d in the second cycle respectively. The dose of Gn and the number of oocytes, zygote and frozen embryos were observed. Results：The dose of Gn in the second cycle was obviously less than that of the first cycle（38.46 ± 10. 13 ampules vs 44.50 ± 13.10 ampules, P 〈 0. 05 ）, the LH level before using Gn was higher than that of the first cycle（2.89 ±0. 41IU/L vs 1.20 ±0.31IU/L,P 〈0.001 ）, the LH and E2 level on the day of HCG was higher than that of the first cycle（3.39 ±0.98IU/L vs 1.25 ± 0.29 IU/L, P 〈 0. 001 ; 6032.11 ± 1011.3 pmol/L vs 4299.81 ± 1122.40pmol/1, P 〈 0. 05 ）, the number of eggs was more than that of the first cycle （6.7 ± 0.32 vs 5.0 ± 0.68,P 〈 0. 05 ） , the number of fertilized eggs and frozen embryos was more than the first cycle （4.9 ± 0. 85 vs 3.49 ± 0.35 ;2.1 ± 0.42 vs 0.97 ± 0.65, P 〈 0. 05 ）. And the duration of using Gn, serum E2 level after down regulation, P level on the day of HCG and high-quality embryo rate between the two cycles had not shown obvious difference. Conclusion：Down-regulation with onethird dose of Decapeptyle on the poor ovarian response patients can get better effect. A satisfactory effect of pregnancy was got with a decreased dose of Gn.
出处
《现代妇产科进展》
CSCD
北大核心
2006年第3期203-205,共3页
Progress in Obstetrics and Gynecology
关键词
受精
体外
胚胎移植
促性腺激素释放激素激动剂
卵巢反应欠佳
Feritilization in vitro
Embro transfer
Gonadotropin-releasing hormone agonist
Poor ovarian response
