摘要
目的探讨内皮素(ET)与流行性乙型脑炎的关系。方法采用放射免疫分析(RIA)法检测52例乙脑患儿血浆及脑脊液中内皮素-1(ET-1)含量。结果乙脑患儿极期血浆及脑脊液中ET-1含量均明显高于对照组(P<0.001),有显著统计学意义。重型乙脑患儿血浆及脑脊液中的ET-1含量均值明显高于普通型乙脑患儿(血浆P<0.01,脑脊液P<0.05)。结论血浆及脑脊液中ET-1含量增高与脑实质损伤程度密切相关,其含量增高可作为脑实质损伤程度的一个重要指标。
To study the relationship between endothelin-1 （ET-1） and epidemic encephalitis B in children, the level of ET-1 in plasma and cerebrospinal fluid was measured in 52 patients with epidemic encephalitis B by using the radioimmunoassay（RIA）. It was found that the level of ET-1 was significantly higher in epidemic encephalitis B than that of controls group （P〈0.001）. and the average value of severe type in the patients with epidemic encephalitis B was significantly higher than that of common type （plasma P 〈0.01, cerebrospinal fluid P〈0.05）. That is to say, the level of ET-1 is elevated in plasma and cerebrospinal fluid of epidemic en- cephalitis B and it is relate to the degree of parenchyrnal lesions of brain. These reseachs suggest that the elevation of ET-1 may be an important marker of the parenchymal lesions of brain in patients with epidemic encephalitis B.
出处
《中国人兽共患病学报》
CAS
CSCD
北大核心
2006年第1期81-82,80,共3页
Chinese Journal of Zoonoses
关键词
流行性乙型脑炎
内皮素-1
血浆
脑脊液
Epidemic encephalitis B
Endothelin-1
Plasma
Cerebrospinal fluid
