摘要
目的：探讨运动对心理应激大鼠行为及血浆皮质酮（CORT）和促肾上腺皮质激素（ACTH）的影响。方法：实验共分为3期：适应期（第1～7天）、复合应激期（第8～14天）及慢性心理应激期（第15天）。适应期选择适应良好、行为评分一致的雄性SD大鼠进行7天暗环境适应，观察大鼠适应过程中的行为变化，取适应良好的大鼠进入复合应激期的实验。将复合应激期大鼠随机分为对照组（C）、对照结合运动组（C＋S）、规则光信号-电刺激组（R）、不规则光信号-电刺激组（I）和不规则光信号-电刺激结合运动组（I＋S）进行实验观察。慢性应激期各组仅保留光刺激，观察大鼠行为改变。实验结束后，测定大鼠血浆ACTH和CORT浓度。结果：大鼠行为评分，I、R组明显高于C组，I＋S组低于I组，但仍高于C组；I、R组的探查行为评分明显低于C组，I＋S组高于I组；I、R组动物体重增长百分数明显低于C组，I＋S组高于I组，但仍低于C组。大鼠血浆ACTH的浓度为I组〉R组〉C组；血浆CORT的浓度为I组〉R组〉C组，其中I组显著高于另两组；I＋S组血浆ACTH、CORT浓度均低于I组，但高于对照组。结论：慢性心理应激能引起大鼠相关应激激素释放增加，行为改变。运动能在一定程度上减轻大鼠不良心理应激反应。
Objective Using animal model, the authors aimed at investigating the effects of chronic psychological stress on rats＇ exploratory actions, and plasma adrenocorticotropin （ACTH） and corticosterone （ CORT）, as well as the mechanism of the effects. Methods Sprague - Dawley rats were undergoing adaptation for a week （adaptive stage）, and those with well- adaptation were selected and then divided into five groups for stress training（combined psychological stress stage） ： group C ＋ S （swimming freely after regular light irritation） and C （without swimming after regular light irritation）, group R（with regular light - electric foot shock）, group I ＋ S（with swimming freely after irregular light - electric foot shock） and I（without swimming after irregular light- electric foot shock）. During the third stage （chronic psychological stress stage）, animals in all groups were only stimulated with light irritation. Rats＇ action scores and body weight were assayed in the three stages. After the training, plasma ACTH, CORT were estimated. Results The action scores in group R and I were higher than that in group C, action scores in group I ＋ S was lower than that in group I, but higher than that in group C and C ＋ S. The numbers of exploratory action in group R and I were lower than that in group C, and the number of exploratory action in group I ＋ S were higher than that in group I. The increasing of body weights weights were significantly lower in group R and in group I ＋ S was higher than that in I as compared with that in group C, and increasing of body group I, but lower than that in group C and C ＋ S. Plasma ACTH concentrations revealed as fouows ： group I 〉 group R 〉 group C, CORT value in group I was significant higher than in the other two. In group I ＋ S, the CORT and ACTH concentrations were lower than that in group I, but higher than that in group C and C ＋ S. Conclusion Chronic psychological stress could induce stress - related hormone excretion and action alteration. Exercise to some degree could mitigate the psychological stress reactions.
出处
《中国运动医学杂志》
CAS
CSCD
北大核心
2006年第1期41-45,共5页
Chinese Journal of Sports Medicine
基金
国家自然科学基金项目(批准号30000060)
上海高校优秀青年教师后备人选课题项目
上海市重点学科建设项目(编号T0901)资助
关键词
运动
心理应激
皮质酮
促肾上腺皮质激素
大鼠
exercise, psychological stress, corticosterone, adrenocorticotropin
