摘要
目的:研究非小细胞肺癌中CD44v6的表达及与其分型、颅内转移的关系。方法:应用免疫组化法检测30例非小细胞肺癌组织标本中CD44v6的表达,并分析其临床意义。结果:CD44v6高表达与非小细胞肺癌的淋巴结转移及颅内转移有关(P<0.05),是非小细胞肺癌颅内转移的主要风险因子。结论:检测CD44v6蛋白的表达,有可能为判断非小细胞肺癌淋巴结转移、颅内转移的发展以及评估预后提供依据。
Aim：To observe the expression of CD44v6 and to discuss the relation of CD44v6 and brain metastases in NSCLC.Methods： The expressions of CD44v6 in 30 NSCLC were detected by using immunohistochemical method. We analysie the relationship of CD44v6 expression in different types of NSCLC, lymph node metastasis and brain metastasis. We also use stepwise COX proportional hazard mode to analyse prognostic factors for brain metastasis in NSCLC. Results： CD44v6 were highly expressed in 20 of 30 cases. There was no relationship in different types of NSCLC , but it was related with lymph node and brain metastasis（ P 〈 0.05） ,and it was a prognostic factor for brain metastasis in NSCLC. Conclusion： CD44v6 is highly expressed in NSCLC. It may be a potential prognostic indicator and may be useful as a predictor for lymph node and brain metastasis in NSCLC.
出处
《中国临床神经科学》
2006年第1期33-36,共4页
Chinese Journal of Clinical Neurosciences
关键词
CD44V6
非小细胞肺癌
脑
转移
CD44v6
non-small cell lung cancer（NSCLC）
brain
metastases
