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阻抗谱分析法测量红细胞聚集特性实验研究

Experiment Study on the Impedance Spectroscopy Analysis Method t o measure RBC Aggregation.
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摘要 为了验证阻抗谱分析法测量红细胞聚集特性的正确性和可行性,本文进行了一系列有针对性的血液学实验以观察血细胞比容,悬浮介质中血浆浓度和右旋糖酐浓度对血液电阻抗参数以及红细胞聚集程度的影响。结果显示,低频下的血液电阻率R0随血细胞比容的增大而增大,血细胞比容从28.9变化到48.9时,时间常数T的变化不大;随血浆浓度的增加,红细胞聚集体的半径增大;当右旋糖酐浓度约为4g/100ml时,红细胞聚集出现一最高值。表明阻抗谱分析法可为红细胞聚集特性提供一种简便、有效的检测手段。 In order to test validity and feasibility of the impedance spectroscopy analysis method, a series of blood experiments have been carried out to study influences of the hematocrit, the plasma concentration and the dextran concentration in suspend medium on the blood impedance and the RBC aggregation.The results show that the blood impedance of lower frequency R0 increases with increase of Hctc, the time constant T has little change when Hctc hange from 28.9 to 48.9; with the increase of plasma concentration, the RBC aggregation radius increases; When the dextran concentration is about 4g/100ml, the RBC aggregate reaches its maximum. It suggests that the impedance spectroscopy analysis method is a new, effective method to study RBC aggregation.
出处 《医学研究杂志》 2006年第2期36-38,共3页 Journal of Medical Research
基金 国家自然科学基金重点项目(50337020)资助
关键词 阻抗谱分析法 红细胞 聚集特性 Impedance spectroscopy analysis Red blood cell (RBC) Aggregation Experiment Study
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参考文献4

  • 1[2]秦任甲主编.血液流变学.北京:人民卫生出版社,2000.
  • 2[4]Alicja Cicha-Mikotajczyk et al,Measurement of blood permittivity in the microwave frequency range.Proceedings of the 11thICEBI,2001,Oslo,Norway:201.
  • 3[5]Cloutier G,Zhao Q.Ultrasound backscattering from non-aggregating and aggregating erythrocytes-a review.Biorheology,1997,34:443-470.
  • 4[6]Zhao TX,Jacobson B,etc.Triple-frequency method for measuring blood impedance.Physiol Meas,1993,14:145-156.

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