期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

化疗和适形放疗同步治疗局部晚期NSCLC临床疗效观察

暂未订购
导出
摘要 目的:观察放、化疗同步治疗局部晚期非小细胞肺癌(NSCLC)的临床疗效及毒副反应。方法:26 例不能手术的局部晚期NSCLC患者采用NP方案化疗和同步三维适形放射治疗,照射剂量为常规分割,每次2Gy、每周5次、累计总量66Gy-70Gy,同步行NP方案化疗4个周期。结果:1年生存率Ⅲa期为72．7％,Ⅲb期为 20．0％。主要毒副反应为骨髓抑制、胃肠道反应、放射性肺炎、放射性食管炎。结论:化疗和三维适形放疗同步治疗局部晚期NSCLC能提高患者的生存时间和生存率,且耐受性较好,值得临床进一步研究。
作者 朱江红 杨胜利 彭明尧 陈丽娟 胡军 代军
机构地区 四川省攀枝花市中心医院肿瘤科
出处 《四川肿瘤防治》 2006年第1期29-30,共2页 Sichuan Journal of Cancer Control
关键词 非小细胞肺癌 三维适形放射治疗 化学治疗
分类号 R734.2 [医药卫生—肿瘤]
  • 相关文献

参考文献6

  • 1Cox JD, Azamia N, Byharrd RW, et al. N2(clinical) non-small cell lung cancer: prospective trials of radiation therapy with total dose 60Gy by the RTOG[J]. Int J Radiat Oncol Biol Phys, 1991,20 ( 1 ) :7-12.
  • 2Enstrom JE, Austin DF. Interpreting cancer survival rate[J]. Science, 1997,1:847-851.
  • 3吴一龙.非小细胞肺癌综合治疗的再认识[J].循证医学,2004,4(4):193-195. 被引量：13
  • 4Fletcher. CH. Clinical dose-response of human malignant epithelial tumors[J]. BRJR adiol. 1973,46:1-12.
  • 5Morris DE, Rosenman JG, Halle JS, et al. Induction chemotherapy followed by dose-escalated thoracic 3-dimensional conformal radiation therapy to 90 Gy with concurrent chemotherapy in stage Ⅲ A/B non-small cell lung cancer: a phase Ⅰ radiation dose escalation trial[J]. Int J Radiat Oncol Boil Phys, 2003,57(2) :138-139.
  • 6蒋国樑.局部晚期非小细胞肺癌的放射治疗[J].中国癌症杂志,2003,13(5):394-397. 被引量：15

二级参考文献16

  • 1[1]Winton T, Livingston R, Johnson D, et al. A prospective randomized trial of adjuvant vinorelbine (VIN) and cisplatin (CIS) in completely resected stage Ⅰ B and Ⅱ non-small cell lung cancer (NSCLC) Intergroup JBR. 10 [C]. Proc Am Soc Clin Oncol, 2004, 23 ( suppl ): 7018a.
  • 2[2]Strauss G, Herndon J, Maddaus M, et al. Randomized clinical trial of adjuvant chemotherapy with paclitaxel and carboplatin following resection in stage Ⅰ B non-small cell lung cancer (NSCLC): Report of Cancer and Leukemia Group B (CALGB)Protocol 9633 [C]. Proc Am Soc Clin Oncol, 2004, 23(suppl):7019a.
  • 3[4]Hotta K, Matsuo K, Ueoka H, et al. Role of adjuvant chemotherapy in patients with resected non-small-cell lung cancer:reappraisal with a rmeta-analysis of randomized controlled trials [J]. J Clin Oncol, 2004, 22(19):3860-3867.
  • 4[5]Zojwalla NJ, Raftopoulos H, Gralla RJ. Are cisplatin and carboplatin equivalent in the treatment of non-small cell lung carcinoma (NSCLC)? Results of a comprehensive review of randomized studies in over 2300 patients [C]. Proc Am Soc Clin Oncol, 2004, 23:7068a.
  • 5[6]Onishi H, Nagata Y, Shirato H, et al. Stereotactic hypofractionated high-dose irradiation for stage Ⅰ non-small cell lung carcinoma:clinical outcomes in 273 cases of a Japanese multi-institutional study [C]. Proc Am Soc Clin Oncol, 2004, 23:7003a.
  • 6[7]Vokes E, Herndon J, Kelly M, et al. Induction chemotherapy followed by concomitant chemoradiotherapy (CT/XRT)versus CT/XRT alone for regionally advanced unresectable non-small cell lung cancer(NSCLC) :Initial analysis of a randomized phase Ⅲ trial [C]. Proc Am Soc Clin Oncol, 2004, 23:7005a.
  • 7Thomas M, Rube C, Semik M, et al. Impact of preoperative bimodality induction including twice-daily radiation on tumor regression and survival in stage Ⅲ non.-mnall-cell lung cancer[J] .J Clin Oncol,1999,17(4) :1185.
  • 8Vora SA, Daly BD, Blaszkowsky L, et al. High dose radiation therapy and chemotherapy as induction treatment for stage Ⅲ non-samll-cell lung carcinoma[ J ]. Cancer,2000,89 (9) : 1946-1952.
  • 9Adelstein DJ, Rice TW, Rybicki LA, et al. Accelerated hyperfractionated radiation, concurrent paclitaxel/cisplatin chemotherapy and surgery for stage Ⅲ non-small-cell lung cancer[ J]. Lung Cancer,2002,36(2) :167-170.
  • 10Suntharalingam M, Sonett JR, Hass ML, et al. The use of concurrent chemotherapy with high-dose radiation before surgical resection in patients presenting with apical sulcus tumors [J ].Cancer J,2000;6(6) :365-371.

共引文献26

四川肿瘤防治
2006年 第1期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部