摘要
目的回顾性分析比较Ⅲ期非小细胞肺癌放化综合治疗与单纯放疗的临床疗效。方法对56例Ⅲ期非小细胞肺癌的患者纳入分析,治疗方法包括单纯放疗(RT组25例)和放化综合治疗(CRT组31例),放疗均采用常规分割,其中常规放疗29例,三维适形放射治疗(3DCRT)27例。综合治疗采用以顺铂为主的联合化疗方案。结果化放组和单放组总有效率(CR+PR)分别为83．9%和76%(P=0．75)。化放组中位生存期18个月,单放组中位生存期10个月,两组1、2、3年总生存率分别为64．5%、41．3%、37．2%和44．0%、26．7%、13．3%(P=0．048)。化放组和单放组2年局部控制率分别为35．0%和13．5%(P=0．077)。全组未出现3级以上食道炎及肺炎,毒副反应发生率在不同治疗组间差别无统计学意义。结论放化综合治疗明显提高Ⅲ期非小细胞肺癌的生存率而未增加毒副反应发生率。
Objective To retrospectively analyze the outcome of stage Ⅲ non-small cell lung cancer （NSCLC） treated with radiotherapy and chemoradiotherapy.Methods 56 patients who were treated with radiotherapy alone （RT group,28cases） or radiotherapy plus chemotherapy （CRT group, 31cases ） were entered into the database for analysis. All patients used the conventional fractionated radiotherapy, including conventional radiotherapy（29 cases） and three dimensional conformal radiation therapy（3DCRT, 27 cases）. The 31 patients treated with combined modality treatment all received cisplatin based chemotherapy. Results The overall response rate of CRT and RT group were 83.9% and 76.0%（ P= 0.75） respectively.The median survival time were 18 months and 10 months, respectively. The 1-, 2-, 3-year overall survival rate were 64.5%, 41.3%, 37.2% for CRT group and 44.0%,26.7% ,13.3% for RT group（ P = 0.0482）.The 2-year local control rate were 31.3 % and 9.3 %, respectively（ P = 0.12）. There was no esophagitis and pneamonitis more than grade 3 in each group. And the differences of toxicity rates between the two groups were statistically insignificant. Conclusion The combination of radiotherapy and chemotherapy improved the overall survival of stage Ⅲ non-small cell lung cancer without increasing toxicity.
出处
《实用肿瘤学杂志》
CAS
2007年第3期204-207,共4页
Practical Oncology Journal
关键词
非小细胞肺癌
放射疗法
三维适形放射治疗
综合治疗
预后
Non-small cell lung Carcinoma/radiotherapy
Three-dimensional conformal radiotherapy
Combined modality treatment
Prognosis
