摘要
采用高效液相色谱法同时测定对乙酰氨基酚、马来酸氯苯那敏的含量。以Eclipse XDB—C18为色谱柱，以甲醇-0．05mol·L^-1磷酸二氢钾-三乙胺（10：90：0．02）（用磷酸调节pH值至3．4）为流动相，以215nm为检测波长，流速为1．0ml·min^-1，柱温为30℃。对乙酰氨基酚在20～80μg范围内线性关系良好，r=0．9991，平均回收率为99．9％，RSD为0．2％；马来酸氯苯那敏在0．08～0．32μg范围内线性关系良好，r=0．9990，平均回收率为99．9％，RSD为0．2％。该质量标准的研究有效控制了小儿氨酚黄那敏片的质量，方法简单、结果准确、灵敏度高。
An HPLC method was established for the determination of paracetamol and chlorphenamine maleate in Xiao＇er Anfen Huang Namin Tablets. The Eclipse XDB--Cls column was used with methanol - 0.05mol·L^-1 potassium dihydrogen phosphate solution - triethylamine （10 ： 90 ： 0.02） as mobile phase （the pH of mobile phase was adjusted to 3.4 with phosphate）. The detection wavelength was 215nm. The flow rate was 1.0ml · min^-1 and the column temperature was 30℃. There was a good linear relationship （r =0.9991） when paracetamol was 20～80μg, the average recovery was 99. 9% and RSD was 0. 2%. And there was a good linear relationship （r=0.9990） when chlorphenamine maleate was 0.08～0.32μg, the average recovery was 99.9% and RSD was 0.2%. The method was simple, accurate, and highly sensitive. It was efficient for the quality control for Xiao＇er Anfen Huang Namin Tablets.
出处
《中国药事》
CAS
2006年第2期105-107,共3页
Chinese Pharmaceutical Affairs
关键词
小儿氨酚黄那敏片
对乙酰氨基酚
马来酸氯苯那敏
高效液相色谱法
pediatric paracctamol
atificial cow - bczoar
chlorphcnamine maleate
Xiao＇er Aanfen Huang Namin Tablets
paracetamol
HPLC
