摘要
本文使用磺胺二甲嘧啶为探测药物分析乙酰化表型在102例妇女乳腺肿瘤(包括良性和恶性肿瘤)和59例健康志愿者中的分布,发现77例乳腺恶性肿瘤病人中,快乙酰化表型所占的比例较之对照组增高16.2％,P<0.05。进一步观察手术和化疗对乳腺癌病人乙酰化水平的影响,发现39例病人手术后,有5例患者的乙酰化率下降值超过了10％,P<0.05;另8例病人化疗后,乙酰化率平均下降了5.2 7±SD3.54％,P<0.01。这一结果提示,切除乳腺肿瘤或抑制其生长,可能导致乙酰化水平的下降。
The distribution of acetylator phenotypes has been determined in 102women with breast tumors, including 25 with benign breast disease and 77 with breast cancer, and compared to that in 59 healthy controls.There was an significant increase(16.2%)of rapid acetylattors in 77 patients with breast cancer, P<0. 05. As a result of the effect of therapy on the rate of acetylation,it was found that in 39 patients with breast cancer the level of acetylation was decreased after mastectomy. The difference of percentage acetylation between preoperation and post-operation was statistically significant, p<0.05. A similar change in 8 patients with breast cancer could be observed after chemotherapy P<0.01. The results obtained in the present studies indicated that there was a significant association between rapid phenotype and breast cancer of women. The mastectomy or inhibition of tumor growth may bring about a decrease in the level of acetylation.
出处
《癌症》
SCIE
CAS
CSCD
北大核心
1990年第3期205-208,共4页
Chinese Journal of Cancer
