摘要
目的 综合评价代谢酶基因多态性与大肠癌危险性的关系。方法 应用Meta分析原理对国内 42篇大肠癌相关代谢酶基因多态性的病例对照研究进行定量综合分析。统计处理采用M H法或D L法以及RevM4 1统计软件包。结果 GSTM1缺陷型、GSTT1缺陷型、GSTP1Llel 10 5Val、NAT1 10、NAT2快速乙酰化表型 /基因型、乙酰化表型、乙酰化基因型、CYP1A1MspI、CYP1A1Lle462Val、MTHFRC677T和MTRA 2 75 9G11个研究因素的综合统计量 (OR值 )分别为 1 0 6、 1 42、 1 0 9、 1 2 5、 1 0 8、 1 15、 1 0 5、 1 2 6、 1 3 0、 0 83和0 60。结论 GSTT1缺陷型、NAT2快速乙酰化表型 /基因型和NAT2快速乙酰化表型可能与大肠癌的发生有关。
Objective To evaluate the relationship between genetic polymorphisms of metabolizing enzyme and colorectal cancer. Methods The results of 42 epidemiological studies from 1990 to 2001 were analyzed by means of Meta analysis. Mantel Haenszel fixed effects model, Dersimonian Lair random effects model and ReviewManager4 1 statistical program were applied in processing data. Results The pooled OR values of GSTM1 deletion, GSTT1 deletion, GSTP1 lle105Val, NAT1*10, NAT2 rapid acetylator phenotype&genotype, NAT2 rapid acetylator phenotype, NAT2 rapid acetylator genotype, CYP1A1 Lle462Val, CYP1A1 MspI*C, MTHFR C677T and MTR A2759G were 1 06, 1 42, 1 09, 1 25, 1 08, 1 15, 1 05, 1 26, 1 30, 0 83 and 0 60 respectively. Conclusions Genetic polymorphisms of colorectal cancer are significantly associated with the GSTT1 deletion, NAT2-rapid acetylator phenotype&genotype and NAT2-rapid acetylator phenotype. [
出处
《浙江预防医学》
2003年第1期1-4,共4页
Zhejiang Journal of Preventive Medicine
基金
国家自然科学基金项目
项目批准号 :30 170 82 8
关键词
大肠癌
代谢酶
基因多态性
META分析
Colorectal cancer Metabolizing enzyme Polymorophism Meta analysis
