基质金属蛋白酶及其组织抑制因子在心肌梗死后心室重构中的作用被引量：9

Roles of Matrix Metalloproteinases and Their Tissue Inhibitors in Ventricular Remodeling after Myocardial Infarction

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摘要心肌梗死后心室重构是心力衰竭产生的重要原因,其中细胞外基质的改建是重要的分子机制。基质金属蛋白酶(MMPs)是降解细胞外基质的重要蛋白水解系统。基质金属蛋白酶组织抑制因子(TIMPs)是MMPs的内源性抑制系统。MMPs/TIMPs平衡失调是心肌梗死后胶原网络重构的重要调节因素之一。现就MMPs和TIMPs在心肌梗死后心室重构中的作用及基质金属蛋白酶抑制剂抗重构治疗的研究进展作一综述。 Ventricular remodeling after myocardial infarction is the main reason of congestive heart failure, and the reconstruction of extracellular matrix is one of the most important molecular mechanisms. Matrix metalloproteinases （MMPs） are an important proteinase system to hydrolyze the components of extracellular matrix. Tissue inhibitors of metalloproteinases（TIMPs） are specific endogenous MMP inhibitors. The imbalance of MMPs and TIMPs is an important regulator of collagen network remodeling after myocardial infarction. The research progresses in the roles of MMPs and TIMPs in ventricular remodeling after myocardial infarction and the anti-remodeling therapy with MMP inhibitors are reviewed.

作者边素艳

机构地区中国人民解放军总医院心内科实验室

出处《现代诊断与治疗》 CAS 2006年第1期27-30,共4页 Modern Diagnosis and Treatment

关键词基质金属蛋白酶基质金属蛋白酶组织抑制因子心肌梗死心室重构 Matrix metalloproteinases Tissue inhibitors of metalloproteinases Myocardial infarction Ventricular remodeling

分类号 R542.22 [医药卫生—心血管疾病]

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