摘要
目的:探讨bax在不同类型子宫内膜腺上皮细胞中表达的意义。方法:采用免疫组化检测不同类型子宫内膜组织中bax的表达。结果:从单纯性增生、复杂性增生到不典型增生,bax的表达评分有逐渐增多趋势,不典型性增生与前二者相比均有显著性差异(分别P<0.01,P<0.05)。在内膜样腺癌中,随着癌组织分化程度的降低,bax蛋白的表达逐渐降低;随着癌组织浸润深度的增加,bax蛋白表达逐渐增加,各组间比较有显著性差异(均P<0.01)。结论:bax参与了癌前病变的发生。在内膜样腺癌中,bax表达与癌细胞的分化程度、肌层浸润深度有关。推测bax表达水平在一定程度上反映了肿瘤的生物学行为,可作为预测预后的指标。
Objective To analyze the expression of bax in the gland epithelial cells of various endometriums. Methods Immunohistochemistry technique was used to detect bax expression in various endometriums. Results Bax was increased from simple hyperplasla,complex hyperplasia to atypical hyperplasia. Bax was higher in atypical hyperplasia than simple hyperplasia and complex hyperplasia, and the differences were significant （P 〈0. 05, respectively）. In the endometrioid adenocarcinoma, poorer of the differentiation grades, shorter of bax expression. More deeper of myometrial invasion, more of bax expression. The means bax expression was associated with differentiation grades and depth of myometrial invasion. Conclusion Bax may participate in the origin of precancerous lesions. In endometrioid adenocarcinoma, bax expression is associated with differentiation grades and depth of myometrial invasion. So to a certain extent, bax expression may reflect the differentiation grades and biological behavior. It could be an important parameter for the prognosis of patients.
出处
《实用诊断与治疗杂志》
2006年第2期108-110,共3页
Journal of Practical Diagnosis and Therapy
