摘要
目的探讨α_１酸性糖蛋白（α_１ＡＧ）在急性白血病化疗和复发中的变化及意义。方法应用Ｌａｕｒｅｌｌ＇ｓ火箭电泳法测定２３例急性白血病患者化疗缓解前后及１２例复发患者血清α_１ＡＧ水平。结果化疗前患者血清α_１ＡＧ为１．２７±０．６４ｇ／Ｌ明显高于正常对照组（０．５０±０．２４ｇ／Ｌ），完全缓解后为０．８０±０．５６ｇ／Ｌ；１２例复发的患者α_１ＡＧ水平升高（１．２７±０．６６ｇ／Ｌ），处于化疗中的患者的α_１ＡＧ值显著高于化疗前。结论α_１ＡＧ检测可用于监测急性白血病患者的化疗过程和复发。
To estimate changes of serum α1-acid glycoprotein(α1AG)during chemotherapy and relapse of acute leukemia.Methods Serum α1 AG levels were meastired in 23 cases of patients with acute leukemia at the time of before and after-treatment and in l2 cases of acute leukemia patients at relapse with Laurell's electrophoresis immune assay.Results The results showed that patients prior to chemotherapy had increased α1AG levels compared with normal controls,1. 27±0.64 g/L vs 0.50±0.24 g/L.α1AG decreased significantly in patients in complete remission with value of 0.80±0.56g/L and rose again coincidentally with relapse,In addition,acute leukemia patients in progress of chemotherapy tended to have higher values of α1AG than before-chemotherapy.Conclusion All of these indicated that serial measurement of α1AG could provide a useful means of monitoring chemotherapy and relapse in acute leukemia.
