摘要
目的探讨胃动素在甲亢性腹泻发病中作用。方法应用放免法对甲亢性腹泻（ＨＤ）、甲亢（ＨＴ）及正常人血浆胃动素水平进行测定。结果治疗前ＨＴ和ＨＤ的胃动素（８９．３±３０．２，１１７．０±２８．３ｐｍｏｌ／Ｌ）高于正常人（６４．５±１５．３ｐｍｏｌ／Ｌ），而ＨＤ又明显高于ＨＴ（Ｐ均＜０．０５）。ＨＤ的腹泻程度和血甲状腺激素水平与胃动素呈正相关。治疗后ＨＴ（６８．１±２７．５ｐｍｏ；／Ｌ）和ＨＤ（８４．８±２９．５ｐｍｏ；／Ｌ）的胃动素与治疗前相比显著降低（Ｐ均＜０．０５），ＨＴ的胃动素恢复到正常，但ＨＤ仍高于正常人（Ｐ＜０．０５）。结论甲亢和甲亢性腹泻患者存在胃肠道激素紊乱，显著升高的胃动素可能与甲亢性腹泻的发病机制有关。
To investigate the effect of motilin in the development of hyperthyroid diarrhea.Methods The plasma motilin levels(PML)were determined by RIA in patients with hyperthyroid diarrhea(HD),hyperthyroidism(HT)and in normal subjects,Results PML were higher than normal(64.5±l5.3 pmol/L)in patients with HT(89.3±30.2 pmol/L)and HD(117.0± 28.3 pmol/L),and were significantly higher in HD than in HT,There was positive correlation between the degree of diarrhea and PML,and between the levels of thyroid hormones and PML.In HT and HD,the PML after treatment were obviously lower than that before treatment(68.1±27.5 pmol/L and 84.8±29.5 pmol/L,respectively vs 89.3 ±30.2 pmol/L and ll7.0±28.3 pmol/L,respectively),and in HT it returned to normal,but in HD it was still higher than normal.Conclusion There is a disorder of gastrointestinal hormones in patients with HT and HD,the significantly raised PML may be relevant to the pathogenesis of HD.
关键词
甲亢
腹泻
胃动素
血浆
hyperthyroidism diarrhea motilin
