摘要
应用放免法对正常人、糖尿病（ＤＭ）和糖尿病性腹泻（ＤＤ）患者血浆胃动素（ＰＭＬ）进行测定。结果ＤＭ和ＤＤ患者的ＰＭＬ均高于正常人，而ＤＤ又明显高于ＤＭ患者。ＤＭ患者治疗前后的ＰＭＬ无明显变化。ＤＤ患者治疗后病情好转者的ＰＭＬ比治前明显下降，而病情无明显好转者治疗前后的ＰＭＬ无明显变化。表明ＤＭ和ＤＤ患者存在胃肠道激素紊乱，显著升高的ＰＭＬ可能与ＤＤ的发病机制有关。
Plasma motilin levels(PML)were measured by radioimmunoassay in normal subjects,diabetics and diabetic diarrhea subjects.The fasting PML were elevated in diabetics(101.2±30.3pmol/L)and diabetic diarrhea subjects(137.0±41.9pmol/L)compared with normal subject;(72.3±20.4pmol/L)and significantly higher in diabetic diarrhea subjects than in diabetics without diarrhea subjects.The PML before(101.2±30.3pmol/L)and after treatment(98.4±31.5pmol/L)in diabetic subjects did not significantly change.The PMLin well-improved diabetic diarrhea subjects were decreased significantly from 143.9 ±37.4 pmol/L before treatment to 102.8±31.6pmol/L after treatment,but the PML before and after treatment in unimproved diabetic diarrhea subjects did not significantly change,131.7±43.6pmol/L and 139.4±40.6pmol/L,respectively. Our data indicate that there is a disorder of gastrointestinal hormones in diabetics and diabetic diarrhea subjects,significantly raised endogenous plasma motilin in diabetic diarrhea may be relevant to the pathogenesis of diarrhea.
关键词
糖尿病
腹泻
胃动素
diabetic diarrhea motilin
