摘要
目的调研不同厂家、规格输液中不溶性微粒的基本情况;定量研究在静脉药物配置中心与普通病房复配的输液中不溶性微粒数量的差异;观察输液器对不溶性微粒的截留作用。方法采用光阻法对输液及在不同环境下配置的复配液进行微粒测定。结果不同厂家输液微粒存在显著性差异;在静脉药物中心内复配的药物微粒数较病房配置的明显减少;经过输液器后所有输液及复配液均符合中国药典关于>100 mL输液不溶性微粒质量标准。结论注射剂及大容量输液的质量、后期复配的环境、操作都是决定输液中微粒的重要因素。输液器是防止输液微粒进入人体的最后一道防线,其作用不容忽视。
OBJECTIVE To investigate the particulate producer matters in different transfusions from different producer, quanti the deviation between the count of particulate matters of the intravenous admixtures prepared in Pharmacy Intravenous Admixture （PIVA） preparing room and the count of unsoluable prepared in common wards and observe the interception of apparatus infusionis for those unsoluable particulates. METHODS The light bloekage method was used to record the count of particulate matters of the transfusions reconstituted in different environments. RESULTS The significant difference of transfusions from different producer was observed. The particulate matter count of the intravenous admixture prepared in PIVA was distinctly less than the count of those prepared in wards. The transfusions and those reconstituted via the apparatus infusionis all meet the limitation （for those volume ≥ 100 mL） of the standards of China Pharmacopeia. CONCLUSION The quality of the injections and high volume transfusions, the reconstituting environments are key factors for the count of particulate matter in the intravenous admixture. Furthermore the apparatus infusionis takes a significant role to prevent the particulate matter in transfusion from getting into human bodies.
出处
《中国药学杂志》
CAS
CSCD
北大核心
2006年第1期45-47,共3页
Chinese Pharmaceutical Journal
关键词
不溶性微粒
注射剂
配置环境
particulate matter
injection
reconstituting enviroument
