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C反应蛋白与2型糖尿病及其大血管病变的关系 被引量：10

Relationship among C-Reactive Protein and Type 2 Diabetes and Macrovasular Complications
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摘要 CRP是一种经典的急性时相反应蛋白,为亚临床系统感染的一个敏感性指标。近年,提出了DM是一种低度炎症性疾病的学说。目前,一些研究提示:CRP可能不但在2型DM及其大血管病变的发生发展中有一定的意义,还直接参与了代谢综合征的发生发展。对2型DM及其大血管病变的预后预测及临床治疗的评估有一定的价值。 C-reactive protein（CRP） is an acute phase protein,which can be used as a sensitive index for subclinical inflammatory disease. In recent years, the theory that diabetes mellitus（ DM ） is a low-grade inflammatory disease has been bring for ward. investigations over the last decade have shown that CRP not only plays a role in the initiation and progression of type 2 DM and its macrovascular complications but also is associated with the initiation and progression of metabolic syndrome. CRP can provide valuable information in the prognostic prediction and assessment of clinical treatment of type 2 DM and its macrovascular complications.
作者 文磊 李博一 宋滇平
机构地区 昆明市第一人民医院 昆明医学院第一附属医院
出处 《医学综述》 2006年第1期22-24,共3页 Medical Recapitulate
关键词 糖尿病 C反应蛋白 大血管病变 代谢综合征 胰岛素抵抗 动脉粥样硬化 Diabetes mellitus C-reactive protein Macrovascularpathy Metabolic syndrome Insulin resistance Atherosclerosis
分类号 R587.2 [医药卫生—内分泌]
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参考文献19

  • 1龙敏.C-反应蛋白和糖尿病[J].国外医学（内分泌学分册）,2002,22(2):75-77. 被引量：78
  • 2Du clos TW. Function of C reactive protein [J]. Ann Med,2000, 32(4) : 274-278.
  • 3Barzilay JI, Abraham L, Heckbert SR, et al. The relation of markers of inflammation to the development of glucose disorders in the elderly:the Cardiovascular Health Study [J]. Diabetea, 2001,50 (10) : 2384-2389.
  • 4Pradhan AD, Manson Jig, Rifai N, et al. C-reactive protein, interleukin 6 ,and risk of developing type 2 diabetes mellitus[J]. JAMA,2001,286(3) : 327-334,.
  • 5Ford ES. Body mass index, diabetes and c-reactive protein among U, S adults[J]. Diabetes Care, 1999,22(12) : 1971-1977.
  • 6Festa AD, Agostino R Jr, Howard G. Chronic subclinical inflammation as part of the insulin resistance syndrome : the Insulin Resistance Athemsehrsis Study(IRAS) [J]. Circulation, 2000,102( 1 ) :42-47.
  • 7Paul M, Ridker MD, Nader R, et al. Comparison of C-reactive protein and low-density lipoprotein cholesterol levels in the prediction of first cardiovascular events[J], N Eng J Med,2002,347(20) : 1557-1564.
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二级参考文献20

  • 1Duclos T W. Function of c-reactive protein [J]. Ann Med, 2000,32:274-278.
  • 2Volanakis J E. Human c-reactive protein: expression,structure, and function [J]. Mol Immunol,2001,38:189-197.
  • 3Ford E S. Body mass index, diabetes, and c-reactive protein among U S adults [J]. Diabetes Care,1999,22:1971-1977.
  • 4Barzilay J I, Abraham L, Heckbert S R, et al. The relation of markers of inflammation to the development of glucose disorders in the elderly: the cardiovascular health study[J]. Diabetes,2001,50:2384-2389.
  • 5Pickup J C, Crook M A. Is type 2 diabetes mellitus a disease of the innate immune system? [J].Diabetologia, 1998,41:1241-1248.
  • 6Pickup J C, Mattock M B, Chusney G D, et al.NIDDM as a disease of the innate immune system:association of acute phase reactants and interleukin-6 with metabolic syndrome X [ J]. Diabetologia, 1997,40:1286-1292.
  • 7Pradhan A D, Manson J E, Rifai N, et al. C-reactive protein,interleukin 6,and risk of developing type2 diabetes mellitus [J]. JAMA,2001,286:327-333.
  • 8Festa A, Agostno R D, Howard G, et al. Chronic subclinical inflammation as part of the insulin resistance syndrome [J]. Circulation, 2000,102:42-47.
  • 9Oaes O N, Akca H, Nayo L D, et al. A phosphatidylinositol 3 - Kinase / Akt / mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-l[J]. Proc Natl Acad Sci USA,2001,10:4640-4645.
  • 10John A, Colwell M D. Inflammation and diabetic vascular complications [J]. Diabetes Care, 1999,22:1927-1928.

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医学综述
2006年 第1期

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