摘要
目的探讨缬沙坦对原发性高血压患者胰岛素抵抗的影响。方法将128例原发性高血压病患者随机分为缬沙坦组68例,硝苯地平组60例;缬沙坦组口服缬沙坦80mg,每日1次,硝苯地平组口服硝苯地平片10mg,每日3次,8周为1疗程;观察治疗前后空腹血糖、餐后2小时血糖、空腹胰岛素、餐后2小时胰岛素及胰岛素敏感性指数的变化。结果两组治疗后血压明显降低(P<0.01),空腹血糖比较差异无统计学意义(P>0.05);缬沙坦组治疗后餐后2小时血糖、空腹胰岛素、餐后2小时胰岛素及胰岛素敏感性指数[(7.73±0.72)mmol/L、(13.84±5.07)mU/L(、58.75±32.05)mU/L、(0.0148±0.0062)]与治疗前[(8.40±0.89)mmol/L(、22.10±8.97)mU/L、(86.70±40.70)mU/L(、0.0078±0.0032)]比较差异均有统计学意义(P<0.01);硝苯地平组治疗前后血糖、胰岛素等指标比较差异无统计学意义(P>0.05)。结论缬沙坦能显著降低原发性高血压患者餐后2小时血糖、提高胰岛素敏感性指标,从而改善胰岛素抵抗。
Objective To explore the effects of valsartan on insulin resistance in patients with primary hypertension. Methods One hundred and twenty-eight patients with primary hypertension were divided randomly into valsartan group and nifedipine group. The valsartan group（ n = 68） was treated with 80 mg valsartan once a day and nifedipine group（ n = 60） with 10 mg nifedipine three times a day. A course lasted for 8 weeks. Before and after treatment,fast blood sugar and 2 hour post-meal blood sugar, fast insulin and 2 hour post-meal insulin and insulin sensitive index were measured. Results Blood pressure in both groups was significantly different after treatment（ P〈 0.01）. Fast blood sugar in both groups was not significantly different before and after treatment（ P 〉0.05）. 2 hour post-meal blood sugar, fast insulin and 2 hour post-meal insulin, insulin sensitive index in the valsartan group were significantly different,before treatment [ （ 8. 40 ± 0. 89 ） mmol/L, （22.10±8.97） mU/L, （86.70±40.70） mU/L, （0.0078±0.0032）] vs after treatment[（7.73±0.72） mmol/L, （13.84±5.07） mU/L, （58.75±32.05） mU/L, （0.0148± 0.0062） ] （P 〈0. 01）, while all the indexes were not different in the nifedipine group（ P 〉 0.05）. Conclusion Valsartan might decrease 2 hour post-meal blood sugar of patients with primary hypertension and increase insulin sensitive index,so as to improve insulin resistance.
出处
《临床荟萃》
CAS
北大核心
2005年第18期1024-1026,共3页
Clinical Focus
关键词
高血压
胰岛素抵抗
缬沙坦
血糖
hypertension
insulin resistance
valsartan
blood glucose
