摘要
本研究主要探讨红丝线草的醇提水转溶物(简称01—w)对哇巴因致豚鼠心律失常和LD_(100)的影响。给药组采用三种不同浓度的01—w并分别与0.0125％的哇巴因同速(0.034ml/min)经豚鼠双侧颈外静脉灌注,对照组单用哇巴因,其浓度及灌注速度同给药组。实验结果表明:0.2g(生药)/ml组能显著提高哇巴因致豚鼠心律失常和LD_(10)的剂量(P<0.01),其它剂量组虽略能提高哇巴因致豚鼠心律失常及LD_(100)的剂量,但无统计学显著性。关于ol—w对抗强心甙毒性作用的机制正在深入研究中,可能与它的心肌保护作用有关。
This paper described the effects of Alcohol extraot of water soluble HSX(ol-w) on ouabain induced arrhythmia and LD_(100) in guinea-pigs. To the administration group: Three doses of ol-w (0.2g/ml, 0.3g/ml, 0.4g/ml) were infused together with 0.0125％ ouabain into vein jugular superficial of guinea-pigs. To the control group: 0.0125％ ouabain was used only for the infusion of vein jugular superficial of the guinea-pigs. The result showed that 0.2g/ml ol-w could increase tremendously the doses of ouabain to produce arrhythmia and LD_(100) (P<0.01), while 0.3g/ml & 0.4g/ml group could inc rease only slightly the doses of cardiotoxicity of ouabain in guinea-pigs(P>0.05), bu insignificantly. The mechanism of ol-w action is under studying and its anticardiotoxicity may be related to its cardiac protecting property.
出处
《暨南大学学报（自然科学与医学版）》
CAS
CSCD
1989年第4期7-11,共5页
Journal of Jinan University(Natural Science & Medicine Edition)
关键词
红丝线带
哇巴因
豚鼠
心律
Herb Hongsixian (ol—w), ouabain Arrhythmia, LD_(100)
