摘要
目的应用Excel电子表格建立HPLC法卡马西平TDM室内质控方法。方法用本实验室建立的卡马西平血药浓度测定方法进行血样及质控品中卡马西平浓度测定,并用Excel电子表格处理质控数据并自动创建室内质控图。结果常规条件下卡马西平已知值质控血清的平均值分别为5.94 mg.L-1,标准差(s)为0.104,相对标准差(RSD)1.8%,3倍RSD值均小于10%,以质控结果超过2S为警告限,超过3S为失控限。结论该方法简单、方便、易于管理,适用于用HPLC法卡马西平TDM的室内质控。
Aim To establish an internal quality control method of TDM for carbamazepine by Excel. Methods Concentration of Carbamazepine was detected with method created in our laboratory,then IQC data was processed and IQC graph was made with Excel. Results The average of concentration is 5.94 mg·L^-1, The standard deviation is 0. 104,and the RSD is 1.8%. We set the result beyond 2S as the level of alarm, and the result beyond 3S as uncontrolled level. Conclusion The method is simple,easy and available. It＇ s suitable for IQC of TDM for carbamazepine by HPLC.
出处
《安徽医药》
CAS
2006年第1期66-67,共2页
Anhui Medical and Pharmaceutical Journal
