摘要
目的:探讨胶质瘤中整合素β1及Ki67的表达及其临床意义。方法:应用免疫组化方法检测45例胶质瘤、5例正常脑组织中整合素β1及Ki67的表达。结果:在Ⅰ、Ⅱ级及Ⅲ、Ⅳ级胶质瘤中,整合素β1的阳性表达率分别为42.11%(8/19)及73.08%(19/26),χ2=4.388,P=0.036;Ki67标记指数分别为(7.06±4.17)%及(13.45±8.69)%,t=3.269,P=0.002,其差异均有统计学意义;且整合素β1的表达与Ki67标记指数具有正相关关系,r=0.71,P=0.000。结论:整合素β1参与胶质瘤的增殖调控,随着整合素β1表达的增高,肿瘤细胞的增殖活性升高,恶性程度增加,并与胶质瘤的侵袭性有关。
Objectives：To investigate the expression of integrinβ1 in gliomas and its biological significance. Methods： Immunohistochemical ashy was used to determine the expression of integrin β1 and Ki-67 nuclear antigen of 45 cases of gliomas and 5 cases of normal brain tissues. Results： For the cases of gliomas with grade Ⅰ-Ⅱ and grade Ⅲ-Ⅳ, the positive expression rates of integrinβ1 were 42.11% （8/19） and 73.08% （19/26） respectively（χ^2 = 4.388, P = 0.036） ; the Ki-67 labeling index were （7.06 ± 4.17）% and （ 13.45 ± 8.69） % respectively（ t = 3. 269, P = 0. 002） The differences were statistical significance Moreover, there was a positive correlation between the expression of integrinβ1 and Ki-67 labeling index（ r = 0.71, P = 0. 000）. Conclusions： Integrinβ1 participates the process of regulating growth of gliomas The proliferative activity and malignant degree of gliomas are related with increase of expression of integrinβ1 Moreover, the expression of integrinβ1 is associated with the invasion of gliomas.
出处
《四川省卫生管理干部学院学报》
2005年第4期241-242,253,共3页
Journal of Sichuan Continuing Education College of Medical Sciences
