摘要
目的:探讨胶质瘤中整合素α3的表达及其生物学意义。方法:用免疫组化方法检测45例胶质瘤、5例正常脑组织中整合素α3以及Ki-67的表达。结果:整合素α3在WHOⅠ、Ⅱ级及WHOⅢ、Ⅳ级胶质瘤中的免疫组化阳性率分别为36.84%、69.23%,有统计学意义(P<0.05);整合素α3的表达与Ki-67标记指数有正相关关系。结论:整合素α3参与胶质瘤的增殖调控,随着整合素α3表达的增加,肿瘤细胞的增殖活性升高,恶性程度增加;并与胶质瘤的侵袭性有关。
Objective：To investigate the expression of integrin α3 in gliomas and its biological significance.Methods：Immunohistochemical assay was used to determine the expression of integrin α3 and Ki-67 nuclear antigen in gliomas （45 cases）and normal brain tissue（5 eases）,Results：The positive expression rates of integrin α3 in gliomas of grade Ⅰor Ⅱand grade Ⅲ or Ⅳ aceording to WHO criferium were 36.84%,69.23%,respectively.It was statistically significante（P〈0.05）,Moreover. there was a positive correlation between the expression of integrin α3 and Ki-67 labeling index.Conclusin：Integrin α3 participated the process of regulating growth of gliomas .The proliferative activity and malignant grade of gliomas correlated to increased expression of integrin α3.Moneover.the expression of integrin α3 was associated with the invasion of gliomas.
出处
《华西医学》
CAS
2005年第3期425-426,共2页
West China Medical Journal
