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胶质瘤中整合素β_1的表达与侵袭性的相关研究

Relationship between the Expression of Integrin β_1 and Invasion in Gliomas
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摘要 目的探讨整合素β1在胶质瘤细胞侵袭过程中的作用。方法用免疫组化方法检测45例胶质瘤、5例正常组织中整合素β1及Ki67的表达。结果整合素β1在WHOⅠ、Ⅱ级及WHOⅢ、Ⅳ级胶质瘤中的免疫组化阳性率分别为42.11%及73.08%,有明显差异(P<0.05);整合素β1的表达与Ki67标记指数具有正相关关系。结论整合素β1参与胶质瘤的侵袭生长过程,随着整合素β1表达的增高,肿瘤细胞的恶性程度增加、侵袭性增强。 Objective To explore the effects of integrinβ1 on mechanism of invasion of gliomas cell line. Methods Immunohistochemical assay was used to determine the expression of integrinβ1 and Ki-67 nu- clear antigen in gliomas （45cases） , normal brain tissues （5 cases）. Results The positive expression rates of integrinβ1 in gliomas of grade Ⅰ.Ⅱ and grade Ⅲ. Ⅳ were 42. 11%, 73.08 %, respectively. It was statistical significance （P〈0. 05）. Moreover, the positive correlation exists between the expression of integrinβ1 and Ki-67 labeling index. Conclusion Integrin β1 participates the process of invasive growth of gliomas. The malignance and invasion of gliomas correlates to increased expression of integrinβ1.
作者 韩杨云 游潮 曾义 徐宏
机构地区 四川德阳市人民医院神经外科 四川大学华西医院神经外科
出处 《肿瘤防治研究》 CAS CSCD 北大核心 2006年第3期178-179,共2页 Cancer Research on Prevention and Treatment
关键词 整合素 胶质瘤Ki-67 免疫组织化学 Integrins Gliomas Ki-67 Immunohistochemistry
分类号 R730.264 [医药卫生—肿瘤]
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参考文献9

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二级参考文献6

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肿瘤防治研究
2006年 第3期

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