摘要
目的应用GK型双叶式人工机械心脏瓣膜(GK双叶瓣)置入动物体内,行瓣膜置换实验研究。方法7只绵羊在体外循环下行二尖瓣或肺动脉瓣置换术,共植入GK双叶瓣7枚(二尖瓣4枚、主动脉瓣3枚)。通过术后循环呼吸系统监测、血生化系统及细菌学检验、血液动力学测定、病理组织学检查,以及长期生存时间和生存质量,综合判断GK双叶瓣的整体性能和对各主要脏器的影响。结果7只动物中1只手术中死亡,6只长期生存(超过30 d),最长生存时间378天。长期生存的动物中未发现感染、栓塞等瓣膜相关并发症。5只动物按计划分别于1、3、6个月处死,尸检观察人工瓣膜表面光滑、启闭自如,各主要脏器包括肺、肾、肝、脾、心肌和脑组织经组织学检查均无栓塞等异常改变。结论GK双叶瓣具有良好的生物相容性、耐久性和血流动力学特性,置入动物体内可获得满意的长期生存效果。
Objective To observe and evaluate the long-term existence result of a new type of bileaflet mechanical prosthetic heart valve（GK bileaflet valve）after its implantation to the animal bodies. Methods Seven sheep were operated upon with either mitral valve or pulmonary valve under the extracorperal circulation, totally 7 GK bileaflet valves were implanted. Through animal general appearance observation, circulation and the breath system monitor, the blood bio-chemical and bacteriologies examination, pathologic histology check, long-term existence time and existence quantity, we analyzed and evaluated the general function of GK bileaflet valves and their effect on the each main organs. Results One animal died during the surgical operations; and 6 animals had long-term existence （over 30 d）,the longest existence time was 378 days. Over a long period of time existent animals, did not appear any infection and the valve-related complications. According to the plan S animals were sent to autopsy in 1,3 and 6 months respectively, the proshetic valvular had smooth surface, opened and closed freely. The embolisms and abnormalities were not found in the main organs including the lung, kidney,liver,spleen, and myocardium during general and histological examinations. Conclusion GK bileaflet prosthetic heart valve exhibits good biological consistency,satisfied durability,and excellent hemodynamic properties. Implanting into the animal body can acquire the satisfied long-term existence result,
出处
《空军总医院学报》
2005年第4期192-195,共4页
Journal of General Hospital of Air Force,PLA
关键词
心脏瓣膜
人工
动物
存活率
Heart valve prosthesis
Animals
Survival rate
