摘要
目的:研究静脉压增高对脑血流的影响.方法:选择W istar雄性大鼠20只,行右颈总动脉和右颈外静脉端端吻合.利用激光多普勒扫描技术测定吻合前、后脑局部脑血流(rCBF)和局部脑血流量(rCBV)的变化,并在吻合2 wk时结扎动静脉吻合部位,同时测量吻合部位结扎前后rCBF和rCBV.结果:与吻合前比较,左侧大脑半球吻合rCBF,rCBV无显著变化,右侧大脑半球吻合后rCBF,rCBV分别由41.9±10.5和1245.1±710.2增高至43.4±10.3和1561.5±850.1(P<0.05),但2 wk后rCBF降至34.5±8.3(P<0.05),rCBV增高至1737.9±1041.8(P<0.05).与吻合部结扎前比较,吻合部结扎后rCBF即刻增高至38.9±6.2(P<0.05),rCBV即刻降低至1000.7±689.5(P<0.05).结论:一侧颈总动脉与颈外静脉吻合模型对研究静脉压增高状态下脑缺血具有实用价值,结扎动静脉短路造成静脉压增高可以明显改善局部脑血流.
AIM:To evaluate the changes of regional cerebral blood flow(rCBF)and regional cerebral blood volume(rCBV)in chronic venous hypertension models of rats.METHODS:Venous hypertension was induced by an endto-end anastomosis between the right carotid artery and the right extemal jugular vein in 20 rats,rCBF and rCBV were assessed by laser Doppler scanning before and after the anastomosis.The region of anastomosis was ligated 2 weeks later and rCBF and rCBV were measured again.RESULTS:Compared with the data before anastomosis,rCBF and rCBV of the left hemisphere did not change,However,in the right hemisphere,rCBF and rCBV significantly increased from(41.9±10.5)and(1245.1±710.2)to(43.4±10.3)and(1561.5±850.1)(P〈0.05),respectively,rCBV significantly increased to(1737.9±1041.8)2 weeks after the bypass but recovered to(1000.7±698.5)after clipping the fistula(P〈0.05)and rCBF significantly decreased to(34.5±8.3)2 weeks after the bypass but recovered to(38.9±6.2)after clipping the fistula(P〈0.05).CONCLUSION:The rat model with an end-to-end anastomosis between a common coronery artery and a homolateral external jugular vein is clinically useful in studying the pathophysiology of chronic venous hypertension.Venous ischemia is reversible,which can be improved by appropriate early treatment.
作者
蒯建科
柴伟
于代华
姚立农
张凤林
赵晖
KUAI Jian-Ke;CHAI Wei;YU Dai-Hua;YAO Li-Nong;ZHANG Feng-Lin;ZHAO Hui(Department of Anesthesiology,Tangdu Hospital,Fourth Military Medical University,Xi'an 710038,China)
出处
《第四军医大学学报》
北大核心
2005年第23期2169-2171,共3页
Journal of the Fourth Military Medical University
关键词
静脉压
局部血流
大鼠
脑血流
venous blood pressure
regional blood flow
rat
