摘要
目的 观察血管紧张素Ⅱ升压化疗法治疗大鼠脑胶质瘤的效果。方法 建立大鼠脑胶质瘤动物模型,采用血管紧张素Ⅱ升压联合化疗的方法治疗胶质瘤,测定局部脑血流和肿瘤局部的药物浓度,观察瘤鼠肿瘤的大小及生存期的变化。结果 联合升压化疗组肿瘤局部血流增加,药物浓度增加,肿瘤鼠的生存期延长。结论 升压化疗法治疗大鼠脑胶质瘤强于未升压化疗法,生存期延长,存活率增加。
Objective: To observe the treatment effect of the rat brain glioma with the chemotherapy and hypertension induced by angiotensinⅡ. Methods: After the model of rat brain glioma was established, Tumour was treated by the therapy with hypertension induced by angiotensinⅡ. The local brain blood flow and local drug concentration of glioma was determined, and the tumorous weight and rat survival time was observed. Reasults: By the chemotherapy and hypertension, both local brain blood flow and local drug concentration increased and survival time was also longer than those without the hypertension. Conclusion: Therapeutic effect on glioma of the rat brain with hypertension is better than that without the hypertension, time and rate also increase.
出处
《泰山医学院学报》
CAS
2005年第1期13-16,共4页
Journal of Taishan Medical College
