摘要
研究了高危人群中HIV/HCV核酸和抗体的关系。从新疆地区采集吸毒人群的血样,并对其进行HIV/ HCV核酸和抗体的检测。320例吸毒人员血浆样品中HCV抗体阳性为80．3％,HIV抗体阳性率为41．9％,HIV 和HCV共感染者为38．3％。HIV RNA与抗体的总符合率为98．8%,在186例HIV抗体阴性样品中可能有2例 为HIV感染的窗口期。HCV抗体和HCV RNA的阳性符合率为92．6％,HCV RNA与HCV抗体的总符合率为 90．0％,以上结果说明在HIV／HCV的高流行区进行HIV／HCV核酸检测可以发现病毒感染的窗口期,而约8% 的HCV抗体阳性样品为病毒核酸阴性,也值得进一步研究。
The objective of this study was to determine the relationship between the nucleic acid and antibody of HIV/HCV in a high-risk population. Plasma samples （320） were collected from drug users in Xinjiang and the nucleic acid and antibody of HIV/HCV were detected. A total of 38% of the subjects were positive for both HIV and HCV. The positive rate of HIV antibody was 41.9%, and the relative coincident rate of HIV RNA and antibody was 98.9%. HIV RNA was detected in 2 cases out of 186 HIV antibody negative cases. The positive rate of HCV antibody was 80.3%, and the positive accordant rate of HCV RNA and antibody is 92.6%, the general accordant rate of those is 90.0%. These results indicated that HIV/HCV infection during the socalled window period can be found by the nucleic acid assay in high-risk areas, however, 8% of HCV antibody positive cases with negative HCV RNA requires further investigations.
出处
《中国病毒学》
CSCD
2005年第6期600-602,共3页
Virologica Sinica
基金
本课题部分受国家科技攻关课题支持(2004BA71907)
关键词
丙型肝炎病毒
人类免疫缺陷病毒
核酸
抗体
核酸检测
Hepatitis C virus （HCV）
Human immunodeficiency virus （HIV）
Nucleic acid
Antibody
Nucleic acid test （NAT）
