摘要
目的:研究β受体阻滞剂和中成药麝香保心丸合用治疗充血性心力衰竭(congestive heart failure,CHF)的临床效果。方法:将156例CHF患者随机分为美托洛尔(m etoprolol,M)组48例、麝香保心丸(shexiang Baoxing P ill SBP)组52例和M-SBP组56例,美托洛尔根据心功能确定首服剂量,麝香保心丸每日3次,每次2粒,共8周。观察治疗前后血浆环核苷酸(环磷腺苷adenosine cyc lophosphate、环磷鸟苷cyc lic guanosine monophosphate)、去甲肾上腺素(norep inephrine,NE)、心钠素(atrial natriuretic peptide,ANP)和心脏射血分数(ejection fraction,EF)、心输出量(card iac output,CO)、心胸比例。结果:M-HMP组治疗效果明显优于单纯M组和SBP组。结论:麝香保心丸和β受体阻滞剂合用可取长补短,是治疗CHF的好办法。
AIM： To research clinical effect of curing patients with CHF （congestive heart failure） with Metoprolol and Shexiang Baoxing Pills （SBP）. METHODS： 156 CHF patients were divided into three groups, including M（Metoprolol） , SBP and M-SBP at random. The first dosage of Metoprolol was specified by the heart function, taking SBP 3 times per day and 2 pieces once, totally 8 weeks. Observeing Plasma Cyclic Nucleotide （ Cyclic Adenosine monophosphate and Cyclic Guanosine Monophosphate）, Norepinephrine （NE） , Atrial Natriuretic Peptide（ANP） and Heart Ejection Fraction（EF）, Cardiac Output（ CO）, heart and chest proportion, Before and after the curing. RESULTS： The curing effect of M-HMP group obviously surpasses simply M group and HMP group. CONCLUSION： Curing CFH patients by metoprolol assistant with SBP is better method.
出处
《中成药》
CAS
CSCD
北大核心
2005年第12期1424-1426,共3页
Chinese Traditional Patent Medicine
关键词
美托洛尔
麝香保心丸
心功能
环核苷酸
去甲肾上腺素
心钠素
Metoproloi
Shexiang Baoxing Pills
heart function
cyclic nucleotide
norepinephine
atrial natriuretic peptide
