摘要
目的：观察老年大鼠血浆环核苷酸的变化及人参，黄芪的调节作用。方法：放射免疫分析法。结果：老年大鼠ｃＡＭＰ，ｃＧＭＰ含量显著高于青年大鼠，但ｃＡＭＰ／ｃＧＭＰ比值降低（Ｐ＜００５），人参，黄芪均可以纠正这三项指标的改变，使之与青年大鼠接近。结论：对血浆环核苷酸的调节是人参和黄芪抗衰老作用的一个方面。
Objective: The plasma cyclic nucleotides contents of aged rats and the regulatory action of Ginseng and Huangqi (Astragalus membranaceus) were studied. Methods: cAMP and cGMP were determined with radioimmunoassay (RIA). Results: It was found that cAMP and cGMP contents of old rats were both significantly higher than young controls, while cAMP/cGMP ratio was significantly lower ( P <0 05). Parallel experiments revealed that when aged rats were treated for 6 months by daily oral administration of Ginseng or Huangqi form 19 months old, the plasma cAMP and cGMP contents were significantly lower than untreated aged rats, while cAMP/cGMP ratio was significantly higher. Conclusion: Ginseng and Huangqi both have an regulatory effect on the plasma cyclic nucleotides of aged rats and this may contribute to their antiagting action.
出处
《河南医学研究》
CAS
1999年第1期33-34,共2页
Henan Medical Research
关键词
人参
黄芪
血浆
环核苷酸
放射免疫法
Ginseng
Astragalus membranaceus
plasma cyclic nucleotides
radioimmunoassay
