摘要
探讨糖尿病大鼠视网膜中央动脉(CRA)的血流动力学变化及灯盏花素的防治作用。用链脲佐菌素(STZ)诱导糖尿病模型后,在第12-13周采用彩色多谱勒对各组视网膜中央动脉(CRA)进行血流参数的测量,包括峰值血流速度(PSV)、舒张期最低流速(EDV)、平均血流速度(MV)、阻力指数(RI)和搏动指数(PI)。糖尿病组大鼠CRA的血流速度较对照组显著降低 (P<0.01),而阻力指数和搏动指数则显著增高(P<0.05)。在灯盏花素治疗组,糖尿病大鼠视网膜血流动力学得到显著改善,与糖尿病纽相比CRA的血流速度显著增加(P<0.01),阻力指数和搏动指数显著降低(P<0.05) 12 周的糖尿病大鼠视网膜已开始出现血流灌注不良和血流减少,但灯盏花素能明显改善糖尿病大鼠的视网膜的血流动力学,增加血流量和灌流量。
To investigate the changes of the retinal blood flow in the diabetic rats by measuring the central retinal artery （CRA） and protective effects of erigeron breviscapus （EB）. After the rats were induced diabetes with stroptozotocin, the circulatory parameters of the central retinal artery （CRA） were measured using color Doppler imaging, including peak systolic velocity （PSV）, end diastolic velocity （EDV）, mean velocity （MV）, resistive index （RI）, and pulsitive index （PI）. The blood velocity in CRA of the diabetic rats was significantly higher （P 〈 0.05 ）. The circulatory parameters in EB-treated diabetic rats were improved significantly. Compared with those in the diabetic rats, the blood velocity in CRA being significantly higher （ P 〈0. 01 ） and RI and PI being significantly lower （ P 〈0. 05 ）. The decreased blood flow and perfusion of the retinal was existed in the 12th week diabetic rat, but efigron breviscapus can improve the retina hemodynamics and increase the retina blood flow and perfusion.
出处
《中山大学研究生学刊（自然科学与医学版）》
2005年第3期34-38,共5页
Journal of the Graduates Sun YAT-SEN University(Natural Sciences.Medicine)
