摘要
目的研究纳豆纤溶酶体外溶栓和溶血作用。方法体外溶栓和溶血实验方法。结果纳豆激酶粗酶(NKc)体外溶栓作用显著,高剂量(2836U)和低剂量(1418U)作用血凝块6h后,溶解率分别为88%和74%,蚓激酶(150000U)为87%;溶血实验结果表明,NKc有溶血作用。结论NKc有溶栓和溶血作用。
OBJECTIVE To study the thrombolytic and hematolytic effect of crude nattokinase in vitro.METHODS Thrombolytic and hemolytic experiment in vitro were conducted. RESULTS After 6 h treatment with crude nattokinase at high dose （2 836 U） and low dose （1 418 U） ,respectively in vitro, 88% and 74% of thrombi were dissolved,respectively, and that of lumbrukinase was 87% .Crude nattokinase haemolyzed rabbit blood red cell. CONCLUSION Crude nattokinase owns thrombolytic and hematolytic function.
出处
《中国药学杂志》
EI
CAS
CSCD
北大核心
2005年第21期1669-1671,1680,共4页
Chinese Pharmaceutical Journal
基金
江西省科技厅项目
赣财教[2003]88号
赣科发计字[2003]188号
关键词
纳豆激酶
体外溶栓
体外溶血
nattokinase
thrombolysis in vitro
hemolysis in vitro
