摘要
目的:探讨中药生脉片防治骨性关节炎的作用机制。方法:通过体外软骨细胞培养的方法,应用IL-1β诱导软骨细胞产生内源性NO,分空白对照组、生脉组、L-NAME组和IL-1β组观察生脉片对软骨细胞一氧化氮合酶(NOS)的影响。结果:生脉组和L-NAME组的NOS活性明显低于IL-1β组(P<0.01)。结论:生脉片能够抑制IL-1β诱导软骨细胞合成NOS,具有防治骨性关节炎的作用。
Objective： To investigate the mechanism of Shengmai tablet, a traditional Chinese medicine, in preventing osteoarthritis. Method： the chondrocyte plates were divided into four groups： Blank control group, Shengmai group, L-NAME group and IL-1β group. The effect of Shengmai tablet on NOS by chondrocyte culture in vitro and the endogenous NO secreted by IL-1β induced chondrocytes was observed. Result： the NOS activity of Shengmai group and L-NAME group were obviously lower than that of IL-1β group （P 〈 0.01 ）. Conclusion： Shengmai tablet can inhibit NOS synthesis of chondrocytes induced by IL-1β, and can prevent and cure osteoarthritis.
出处
《安徽中医学院学报》
CAS
2005年第5期37-39,共3页
Journal of Anhui Traditional Chinese Medical College
基金
国家中医药管理局科研基金项目(95B132)
关键词
骨性关节炎
软骨细胞
一氧化氮合酶
生脉片
Osteoarthritis
Chondrocyte
Nitric oxide synthesis
Shengmai tablet
