摘要
为探讨鼻咽癌细胞人白细胞DR（HLA－DR）抗原表达与临床和预后的关系，采用免疫组化ABC方法检测77例鼻咽癌组织中HLA－DR抗原表达情况，并分析了该抗原表达与鼻咽癌临床病理及预后的关系。结果显示44．2％（34例／77例）的鼻咽癌细胞表达HLA－DR抗原，而癌旁非肿瘤上皮细胞中该抗原阴性。HLA－DR抗原表达与鼻咽癌临床分期关系密切。随肿瘤进展，其阳性率呈阶梯状下降，不同临床分期肿瘤间该抗原阳性率差异存在显著性（Pw＜0．05）。随访8年以上的资料分析表明HLA－DR抗原阳性鼻咽癌的预后非常显著地优于该抗原阴性的鼻咽癌（P＜0．01）。以上结果提示HLA－DR检测对于评估鼻咽癌预后有所帮助，支持肿瘤细胞可能产生免疫调节作用的观点。
In order to clarify the relationship between HLA-DR antigen expression of nasopharyngeal carcinoma (NPC) and the clinicopathology and prognosis of NPC, immunohistochemical studies on HLA-DR antigen expression in 77 NPC cases were performed. The results showed that the posltive rate of HLA-DR was 44. 2% in this series. Non-neoplastic epithelium did not express this antigen. A close association was found between expression of HLA-DR antigen and the clinical staging of NPC. The POsitive rate of HLA-DR gradually decreased with tumor progression, showing a remarkable difference among tumors in different clinical stages (P<0.05). Analysis of patient survival demonstrated that the prognosis of NPC patients with HLA-DR expression was significantly better than those without (P<0.01). The above results give support to the possibility of immunomodulation of tumors.
出处
《中华病理学杂志》
CAS
CSCD
北大核心
1996年第3期162-164,共3页
Chinese Journal of Pathology
基金
湖南省卫生厅基金
