摘要
采用脑内微透析技术研究活体大鼠海马脑区的相关神经递质在操作式条件反射中的动态变化。结果发现,规律游泳的实验组大鼠操作式条件反射形成更快,其海马脑区谷氨酸和GABA的基础值明显比对照组高,且在大鼠进行条件反射操作的过程中它们的上升幅度也比对照组动物高。结果说明,海马脑区兴奋性谷氨酸能神经元活性增强及抑制性GABA能神经元的调控作用增强使游泳大鼠更快建立条件反射。认为规律的游泳运动可以改善脑内神经元的兴奋性,改变神经元之间突触联系的可塑性,从而促进大鼠的操作式条件反射建立。
We studied the activity of hippocampal GABAergic and glutamatergic system and the glucose level in hippocampus after the construction of operant conditioned reflex in the rat. SD rats were randomly assigned to control and exercised groups. Exercise groups were exposed to a swimming regime of 1 h a day,6 days a week.After two weeks of swimming regime, both groups of rats simultaneously underwent the training for operant conditioned reflex in Skinner＇s box.The construction of operant conditioned reflex was established much quickly in exercise group.When the operant conditioned reflex was constructed,in vivo brain microdialysis was used to determine the basal concentration of glutamate and GABA in the extracellular fluid of the hippocampus before, during and after the operation in rats. Throughout the operation, the concentration of glutamate and GABA in the hippocampus of exercise group was obviously higher than the concentration of control group. These findings suggest, first, that regular swimming training improves some cognitive functions in rats, second, one mechanism of the cognitive improvement is via increased concentration of glutamate and GABA in the hippocampus. The mechanism is consisted with the increase of long term potentiation and the decrease of oxidative damage in rat brain.
出处
《天津体育学院学报》
CAS
CSSCI
北大核心
2005年第6期13-17,共5页
Journal of Tianjin University of Sport
基金
北京市教委科技发展规划项目(项目编号:8209-0528)
