摘要
本文报道了人参根总甙对两组不同年龄的雌性大鼠的大脑皮质、下丘脑和脑干的氨基酸类递质和单胺类递质含量的影响。结果表明:人参根总甙显著地降低中年大鼠大脑皮质和脑干的谷氨酸(Glu)含量、脑干的天门冬氨酸(Asp)含量、下丘脑的5—羟色胺(5-HT)含量,增高下丘脑的 r-氨基丁酸(GABA)含量,大脑皮质和脑干的牛磺酸(Tau)含量,下丘脑和脑干的去甲肾上腺素(NE)和多巴胺(DA)的含量。显著降低老年大鼠大脑皮质和脑干的 Glu 含量:大脑皮质的 Asp 含量、大脑皮质和下丘脑的 5-HT 含量。增高大脑皮质的 GABA 含量、下丘脑的 DA 含量,对其他部位无明显作用。人参根总甙的这些作用,可能是其抗衰老作用的一个环节。
Department of Biochemistry,Norman Bethune University of Medical Science This article reported the effects of TSPG on the contents of theamino-acid transmitter and monoamine transmitter in the cerebralcortex,thalamus and pontine in the two groups of female rats withdifferent ages.The results showed that the contents of Glu in thecortex and pontine,Asp in the pontine and 5—HT in the thalamusdecreased obviously by TSPG,but the contents of GABA in thethalamus,Tau in the cortex and pontine,NE and DA in the thalamusand pontine increased in middle-aged rats.In old-aged rats,thecontents of Glu in the cortex and pontine,Asp in the cortex,5—HTin the cortex and thalamus decreased significantly by TSPG,but thecontents of GABA in the cortex,DA in the thalamus increased.Theresults indicated taht these effect of TSPG may be one link of theirantisenile actions.
关键词
人参根总甙
氨基酸类递质
抗衰老
total saponins of Panax ginseng roots
nervous transmitter
antisenile action
