摘要
目的回顾几种梅毒实验室检测方法在硬下疳患者中的梅毒检出率,分析各检测指标间的相互关系,探讨其临床意义。方法每个患者同时进行暗视野检测(DF)、快速血浆反应素试验(RPR)和梅毒螺旋体明胶颗粒凝集试验(TPPA)检测抗体。对实验数据进行统计分析和检验。结果456例患者检测的敏感性分别为DF72.8%,TPPA83.6%,RPR62.7%(配对χ2检验,P<0.001)。结论为了提高一期梅毒的检出率,对疑似梅毒硬下疳的患者,应同时进行3种方法检查。
Objective To evaluate the sensitivity of laboratory diagnostic methods （dark-field microscopy,RPR and TPPA） and their applications for the diagnosis of primary syphilis. Methods It was a retrospective study of 456 patients with primary genital ulceration,and who were diagnosed of and treated with primary sysphilis. The results of the laboratory examinations, including dark-fiehl microscopy of the ulcerative lesions, RPR and TPPA, were collected and analyzed. Results All the 456 patients with genital ulcerations were confirmed to have primary syphilis based on the physical examination, history,laboratory tests,as well as response to anti-syphilis treatment. The sensitivity of the examinations for these patients was 72.8% ,83.6% or 62.7% for dark-field microscopy ,TPPA and RPR, respectively. The sensitivity of the methods was significant different with TPPA as the highest and RPR as the lowest （ P 〈 0. 001 ）. Conclusion For increase the positive rate of the diagnosis of early primary syphilis on all anogenital ulcers and suspected syphilitic lesions, A combination of the three assays （dark-field microscopy, RPR and TPPA） is recommended for STD clinic patients with typical genital ulcerative lesions.
出处
《中国皮肤性病学杂志》
CAS
北大核心
2005年第10期617-618,共2页
The Chinese Journal of Dermatovenereology
基金
上海市自然科学基金课题资助(02ZB14084)
上海市卫生局科学基金资助(1425)
