摘要
应用微生物法测定６名健康志愿者多次口服氧氟沙星片达稳态后的血清药物浓度，药物体内过程符合一室模型，其主要药物动力学参数分别为：Ｔ＿（１／２）＝３．７４±０．４６ｈ；Ｖｃ＝１．５９±０．４５Ｌ／ｋｇ；Ｃ＿（ｍａｘ）＝２．６２±０．４２μｇ／ｍｌ；Ｔｐ＝１．２±０．５５ｈ。测定方法平均回收率为９９．２％。
erum concentration of ofloxacin was determined by microbiological assay in 6 healthy volunteers after oral ad-ministration of multiple dose. The drug in vivo fitted in with one compartment model. The main pharmacokineticparameters of ofloxacin were as follow: T1/2 = 3. 74 ± 0. 46h;Vc =1. 59± 0. 45L/kg; Cmax=2. 62 ± 0. 4 μg/ml;Tp=1. 2±0. 55h. The average recovery was 99. 2/00.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
1996年第4期147-148,共2页
Chinese Journal of Hospital Pharmacy
关键词
氧氟沙星
药代动力学
微生物法
Ofloxacin,pharmacokinetics,microbiological assay
