摘要
本组应用阿霉素苯乙烯微囊肝动脉栓塞治疗晚期肝癌14例。药动学监测示血液浓度低,无明显高峰浓度,半衰期长(t1/2=4.20±2.90天)。病人症状均有改善,42.8％病人肿块缩小。生存期延长,生存质量提高。主要不良反应为轻、中度栓塞后综合征,无严重并发症。笔者讨论了阿霉素微囊栓塞后的体内药物动态行为、临床应用方法和病例选择等问题。
Studies of pharmacokinetics and clinical use were done in 14 patients with HCC treated with chemoembolization of adriamycin microcapsule. The characteristics of pharmacokinetics were low concentration of adriamycin in blood, prolonged half life (t1/2 = 4. 20±2. 90 days) and no apparent peak concentration. Clinical symptoms were mitigated in all the patients. The size of carcinoma was reduced in 42. 8% of patients. Lifetime was prolonged and life quality was improved. The side effects included mild or middle postembolization syndrome. The authors discussed the dynamic behavior of adriamycin microcapsule in human body, clinical use and selection of the patients who was suitable to the procedure.
出处
《影像诊断与介入放射学》
1996年第1期7-9,共3页
Diagnostic Imaging & Interventional Radiology
关键词
肝癌
阿霉素微囊
栓塞疗法
药代动力学
Adriamycin Microcapsule Liver Cancer Embolization Pharmacokinetics
