摘要
目的:制备冬凌草素载药纳米粒,对粒子形态、大小、载药量等进行了表征。方法:以辛酸亚锡为催化剂,通过PEG端羟基引发了己内酯开环聚合而得PCL-PEO-PCL嵌段共聚物;聚合物在选择性溶剂中可形成胶束样纳米粒。结果:纳米粒在扫描电镜下观察呈规则的球形,Zeta电位测定其表面电荷最大值可达-30mV,动态光散射检测粒径在200nm左右,纳米粒的临界胶团浓度较低;而载药量较高,可达到9%左右。结论:PCL-PEO-PCL聚合物纳米胶束可作为冬凌草素的新型药物输送系统。
AIM： To prepare and characterize oridonin-loaded nanoparticles. METHOD： The PCL-PEO-PCL copolymers were synthesized by ring opening polymerization of caprolactone initiated by the hydroxyl groups of poly （ethylene glycol） （PEG） with stannous octoate as catalyzer. In optional solvents these copolymers could form micelles-like nanoparticles（Nps）. RESULT： From SEM the drugloaded Nps exhibited a regular spherical shape. The particles size and size distributing obtained by dynamic light scattering（DIS） of the Nps were about 200 nm, while the highest Zeta potential almost - 30 mV. The critical micelle concentrations （CMC） of the Nps in water were comparatively low while their drug loading content is relatively high （about 9% ）. CONCLUSION： The Oridonin-loaded Nps used as New Drug Delivery System is promising and deserved to deepen its research.
出处
《中国天然药物》
SCIE
CAS
CSCD
2005年第5期291-293,共3页
基金
上海市科委纳米专项基金(课题编号:0243nm026)~~
